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Possible role and therapeutic target of PDGF-D signalling in colorectal cancer
Department of Laboratory Medicine, Division of Medical Diagnostics, Region Jönköping County, Jönköping, Sweden.
Jönköping University, School of Health and Welfare, HHJ, Dep. of Natural Science and Biomedicine. Jönköping University, School of Health and Welfare, HHJ. Biomedical Platform.
Genome Analytics, Helmholtz Centre for Infection Research, Braunschweig, Germany.
Division of Drug Research, Department of Medicine and Health Sciences, Faculty of Medicine and Health Sciences, Linköping University, Linköping, Sweden.
2019 (English)In: Cancer Investigation, ISSN 0735-7907, E-ISSN 1532-4192, Vol. 37, no 2, p. 99-112Article in journal (Refereed) Published
Abstract [en]

Platelet-derived growth factor D (PDGF-D) has been shown to mediate cellular processes of importance in cancer progression. This study aimed to investigate the expression and putative involvement of PDGF-D signaling in colorectal carcinogenesis. PDGF-D was expressed in vascular endothelial cells in tumor and normal tissues. PDGF-D stimulation of cells altered genes of importance in carcinogenic processes. In addition, PDGF-D increased the proliferation rate while imatinib inhibited these effects. PDGF-D and its PDGF receptor beta (PDGFR-β) are expressed in colorectal cancer and blockage of PDGF-D/PDGFR-β signaling using tyrosine kinase inhibitors, such as imatinib, might be important in inhibiting tumor-promoting actions.

Place, publisher, year, edition, pages
Taylor & Francis, 2019. Vol. 37, no 2, p. 99-112
Keywords [en]
Angiogenesis, Colorectal cancer, Imatinib, PDGF-D, Proliferation
National Category
Cancer and Oncology
Identifiers
URN: urn:nbn:se:hj:diva-43312DOI: 10.1080/07357907.2019.1576191ISI: 000462343500005PubMedID: 30836770Scopus ID: 2-s2.0-85062496184Local ID: ;HHJBiomedicinISOAI: oai:DiVA.org:hj-43312DiVA, id: diva2:1295147
Available from: 2019-03-11 Created: 2019-03-11 Last updated: 2019-04-11Bibliographically approved

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Dimberg, Jan

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