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Interaction among smoking status, single nucleotide polymorphisms and markers of systemic inflammation in healthy individuals
Department of Medical Technology, Naresuan University, Phitsanulok, Thailand.
Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden.
Department of Medical Technology, Naresuan University, Phitsanulok, Thailand.
Jönköping University, School of Health and Welfare, HHJ. Biomedical Platform. Department of Laboratory Medicine, Ryhov Hospital, Jönköping, Sweden; and Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden.
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2018 (English)In: Immunology, ISSN 0019-2805, E-ISSN 1365-2567, Vol. 154, no 1, p. 98-103Article in journal (Refereed) Published
Abstract [en]

Cigarette smoke contains toxic and carcinogenic substances that contribute to the development of cancer and various diseases. Genetic variation might be important, because not all smokers develop smoking-related disease. The current study addressed the possible interactions among selected single nucleotide polymorphisms (SNPs) in genes related to systemic inflammation, smoking status, the levels of circulating immune response cells and plasma biomarkers of systemic inflammation. Sixty-four healthy blood donors were recruited, 31 of whom were current smokers and 33 were never-users of tobacco products, references. Compared to references, the smokers showed significantly increased levels of circulating total white blood cells, lymphocytes, monocytes, neutrophils, basophils and C-reactive protein (CRP). Smokers also more frequently exhibited circulating cell phenotypes that are associated with an immunocompromised state: CD8dim cells in the lymphocyte group, CD13+CD11+, CD13+CD14+, CD13+CD56+ cells in the monocyte group and CD13+CD11+, CD13+CD56+ cells in the neutrophil group. We observed an interaction among SNPs, smoking status and some of the studied biomarkers. The average plasma CRP level was significantly higher among the smokers, with the highest level found among those with the CRP rs1800947 CC genotype. Additionally, an increased CD8+GZB+ cells in the CD8dim group were found among smokers with the GZB rs8192917 AA genotype. Thus, smoking appears to be associated with systemic inflammation and increased levels of circulating immunosuppressive cells. The extent of these effects was associated with SNPs among the smokers. This observation may contribute to a better understanding of the genetic susceptibility of smoking-related disease and the variations observed in clinical outcomes. 

Place, publisher, year, edition, pages
John Wiley & Sons, 2018. Vol. 154, no 1, p. 98-103
Keywords [en]
cigarette smoking, immune response, single nucleotide polymorphisms, systemic inflammation, biological marker, C reactive protein, CD11 antigen, CD14 antigen, CD56 antigen, microsomal aminopeptidase, autacoid, granzyme, GZMB protein, human, perforin, adult, Article, basophil, CD3+ T lymphocyte, CD4+ T lymphocyte, CD8+ T lymphocyte, controlled study, female, gene frequency, genotype, human, human cell, human experiment, inflammation, leukocyte, lymphocyte, male, middle aged, monocyte, neutrophil, normal human, priority journal, protein blood level, single nucleotide polymorphism, smoking, tobacco, blood, case control study, genetic predisposition, genetics, immunocompromised patient, immunology, leukocyte count, phenotype, risk factor, Biomarkers, C-Reactive Protein, Case-Control Studies, Genetic Predisposition to Disease, Granzymes, Healthy Volunteers, Humans, Immunocompromised Host, Inflammation Mediators, Polymorphism, Single Nucleotide, Risk Factors
National Category
Immunology
Identifiers
URN: urn:nbn:se:hj:diva-42805DOI: 10.1111/imm.12864ISI: 000430291800011PubMedID: 29140561Scopus ID: 2-s2.0-85039715234Local ID: HHJBiomedicinISOAI: oai:DiVA.org:hj-42805DiVA, id: diva2:1284604
Funder
Futurum - Academy for Health and Care, Jönköping County Council, Sweden, 144631Medical Research Council of Southeast Sweden (FORSS), 567001Available from: 2019-02-01 Created: 2019-02-01 Last updated: 2019-02-01Bibliographically approved

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