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Individual genetic variation might predict acute skin reactions in women undergoing adjuvant breast cancer radiotherapy
Department of Oncology, Ryhov County Hospital, Jönköping, Sweden.
Futurum - The Academy for Healthcare, Region Jönköping County, Jönköping, Sweden.
Department of Oncology, Ryhov County Hospital, Jönköping, Sweden.
Jönköping University, School of Health and Welfare, HHJ. Biomedical Platform. Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden; and Department of Laboratory medicine, Region Jönköping County, Jönköping, Sweden.
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2018 (English)In: Anticancer Research, ISSN 0250-7005, E-ISSN 1791-7530, Vol. 38, no 12, p. 6763-6770Article in journal (Refereed) Published
Abstract [en]

Adverse skin reactions during radiotherapy (RT) are common. The aim of this study was to explore whether genetic variation might be linked to acute radiation skin reactions (ARSR). Materials and Methods: One hundred and nineteen women undergoing adjuvant RT for breast cancer were included. The symptoms of itching, burning and irritation were self-reported twice using the visual analogue scale. Assessments used the Radiation Therapy Oncology Group scoring system for acute RT skin reaction (RTOG scale). Blood-based single nucleotide polymorphism (SNP) analysis was performed. Thirty SNPs of well-defined functional genes were investigated. Results: All women were assessed with ARSR. After RT, the women self-reported itching (n=97), burning (n=64) and irritation (n=96). Two SNPs in X-Ray Repair Cross Complementing 2 gene (XRCC2) rs2040639 and interferon gamma (IFNG) rs2069705 genes were found to be associated with ARSR. Conclusion: An association between two SNPs and ARSR was found. The possibility of using these SNPs as prognostic biomarkers for ARSR as tools to improve the care of patients needs further investigation. 

Place, publisher, year, edition, pages
International Institute of Anticancer Research , 2018. Vol. 38, no 12, p. 6763-6770
Keywords [en]
Breast cancer, Radiotherapy, Single nucleotide polymorphism, Skin reactions, cyclophosphamide, epirubicin, fluorouracil, gamma interferon, xeroderma pigmentosum group D protein, DNA binding protein, IFNG protein, human, tumor marker, XRCC2 protein, human, adjuvant radiotherapy, adult, Article, cancer prognosis, cohort analysis, female, gene function, genetic association, genetic variation, human, middle aged, partial mastectomy, priority journal, radiation dermatitis, scoring system, self report, skin burning sensation, skin irritation, skin pruritus, acute disease, aged, breast tumor, dna mutational analysis, genetic predisposition, genetics, prognosis, very elderly, Aged, 80 and over, Biomarkers, Tumor, Breast Neoplasms, Cohort Studies, DNA-Binding Proteins, Genetic Predisposition to Disease, Humans, Interferon-gamma, Polymorphism, Single Nucleotide, Radiodermatitis, Radiotherapy, Adjuvant
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Cancer and Oncology
Identifiers
URN: urn:nbn:se:hj:diva-42804DOI: 10.21873/anticanres.13047ISI: 000451742800022PubMedID: 30504388Scopus ID: 2-s2.0-85057535771OAI: oai:DiVA.org:hj-42804DiVA, id: diva2:1284598
Funder
Knut and Alice Wallenberg FoundationFuturum - Academy for Health and Care, Jönköping County Council, SwedenMedical Research Council of Southeast Sweden (FORSS)Available from: 2019-02-01 Created: 2019-02-01 Last updated: 2019-02-01Bibliographically approved

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