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Genetic influences on body mass index across Adulthood and late-life
Jönköping University, School of Health and Welfare, HHJ, Institute of Gerontology. Jönköping University, School of Health and Welfare, HHJ. ARN-J (Aging Research Network - Jönköping).ORCID iD: 0000-0003-3605-7829
Jönköping University, School of Health and Welfare, HHJ, Institute of Gerontology. Jönköping University, School of Health and Welfare, HHJ. ARN-J (Aging Research Network - Jönköping).
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Department of Psychology, University of California, Riverside, USA.
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2018 (English)In: Innovation in Aging, ISSN 1556-343X, Vol. 2, no suppl_1, p. 620-620Article in journal, Meeting abstract (Refereed) Published
Abstract [en]

Although genetic factors significantly contribute to variation in body-mass index (BMI), the effects appear to differ with age. To investigate this, we applied polygenic methods to longitudinal data from the Swedish Twin Registry where BMI was available for age categories ranging from 20–35 to above 80. Using GCTA, a polygenic method to estimate heritability, we showed that heritability explains around 20% of the variability in BMI across age categories. However, a polygenic risk score based on the largest GWAS of BMI (PRSBMI) explained 4–6% of the variation in BMI before 65, but less than 0.5% after age 65. This indicates that while there is substantial heritability of BMI across adulthood and late-life, the genetic variants identified in GWAS mainly predict BMI before age 65. Hence, more work is warranted studying the genetics of BMI in late-life, to better understand its biology and what distinguishes it from BMI earlier in adulthood.

Place, publisher, year, edition, pages
Oxford University Press, 2018. Vol. 2, no suppl_1, p. 620-620
National Category
Gerontology, specialising in Medical and Health Sciences
Identifiers
URN: urn:nbn:se:hj:diva-42749DOI: 10.1093/geroni/igy023.2311Local ID: HHJARNISOAI: oai:DiVA.org:hj-42749DiVA, id: diva2:1282198
Conference
The Gerontological Society of America's 70th Annual Scientific Meeting, Boston, November 14-18, 2018
Available from: 2019-01-24 Created: 2019-01-24 Last updated: 2019-01-24Bibliographically approved

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Karlsson, Ida K.Hallgren, JennyDahl Aslan, Anna K.

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CiteExportLink to record
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  • apa
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