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Predictors of improvement in arrhythmia-specific symptoms and health-related quality of life after catheter ablation of atrial fibrillation
Department of Internal Medicine, County Hospital Ryhov, Jönköping, Sweden.
Department of Medical and Health Sciences, Linköping University, Linköping, Sweden.
Department of Internal Medicine, County Hospital Ryhov, Jönköping, Sweden.ORCID iD: 0000-0003-2632-4065
Department of Medical and Health Sciences, Linköping University, Linköping, Sweden.
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2018 (English)In: Clinical Cardiology, ISSN 0160-9289, E-ISSN 1932-8737, Vol. 42, no 2, p. 247-255Article in journal (Refereed) Published
Abstract [en]

Background: The primary goal of radiofrequency ablation (RFA) of atrial fibrillation (AF) is to improve symptoms and health-related quality of life (HRQoL). However, most studies have focused on predictors of AF recurrence rather than on predictors of improvement in symptoms and HRQoL.

Hypothesis: We sought to explore predictors of improvement in arrhythmia-specific symptoms and HRQoL after RFA of AF, and to evaluate the effects on symptoms, HRQoL, anxiety, and depression. Methods: We studied 192 patients undergoing their first RFA of AF. The Medical Outcomes Study 36-Item Short-Form Health Survey (SF-36), arrhythmia-specific questionnaire in tachycardia and arrhythmia (ASTA), and hospital anxiety and depression scale (HADS) questionnaires were filled out at baseline, at 4 months, and at a 1-year follow-up.

Results: All questionnaire scale scores improved significantly over time. In the ASTA symptom scale score, female gender and > 10 AF episodes the month before RFA were significant positive predictors of improvement, while diabetes and AF recurrence within 12 months after RFA were significant negative predictors (R2 = 0.18; P < 0.001). In the ASTA HRQoL scale score, the presence of heart failure and > 10 AF episodes the month before RFA were significant positive predictors of improvement, while diabetes, maximum left atrial volume and AF recurrence were significant negative predictors (R2 = 0.20; P < 0.001).

Conclusion: Left atrial volume, gender, diabetes, heart failure, the frequency of AF attacks prior to RFA, and recurrence of AF after RFA were significant factors affecting improvement in symptoms and HRQoL after RFA of AF. Future studies are warranted to confirm these findings. 

Place, publisher, year, edition, pages
John Wiley & Sons, 2018. Vol. 42, no 2, p. 247-255
Keywords [en]
atrial fibrillation, catheter ablation, health-related quality of life, symptom burden
National Category
Cardiac and Cardiovascular Systems
Identifiers
URN: urn:nbn:se:hj:diva-42438DOI: 10.1002/clc.23134ISI: 000458424300006PubMedID: 30548275Scopus ID: 2-s2.0-85058998671OAI: oai:DiVA.org:hj-42438DiVA, id: diva2:1275627
Available from: 2019-01-07 Created: 2019-01-07 Last updated: 2019-08-14Bibliographically approved

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