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Salivary microbial profiles in 5-year old children with oral clefts: a comparative study
Jönköping University, School of Health and Welfare, HHJ. Oral health. Department of Paediatric Dentistry, Institute for Postgraduate Dental Education, Jönköping, Sweden.
Department of Clinical Dentistry, The Arctic University of Norway, Tromsø, Norway.
Department of Oral Microbiology and Immunology, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.
Dentofacial Orthopedics, Maxillofacial Unit, Linköping University Hospital, Linköping, Sweden.
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2018 (English)In: European Archives of Paediatric Dentistry, ISSN 1818-6300, E-ISSN 1996-9805, Vol. 19, no 1, p. 57-60Article in journal (Refereed) Published
Abstract [en]

Aim: To compare the salivary microbial profile in children with oral clefts to matched non-cleft controls in a cross-sectional study.

Methods: The cleft group consisted of 80 children aged 5 years and 144 age-matched non-cleft children were recruited as a control group. Stimulated whole saliva samples were collected and analysed with checkerboard DNA–DNA hybridisation using 12 pre-determined bacterial probes. Background data on caries, oral hygiene, dietary habits and fluoride exposure were collected from clinical examinations and questionnaires.

Results: Children in the cleft group had a significantly higher prevalence of dental caries but only minor differences in the salivary microbial profile were found. In general, the cleft-children displayed a lower prevalence of common commensal species (e.g. Streptococcus, Fusobacterium) when compared with the non-cleft controls. The differences were statistically significant (p < 0.05) but the clinical significance was unclear.

Conclusions: The profile of the salivary microflora in 5-year-old children with and without oral clefts was basically similar and displayed only marginal differences with respect to commensal bacteria. 

Place, publisher, year, edition, pages
Springer, 2018. Vol. 19, no 1, p. 57-60
Keywords [en]
Caries, Children, Cleft lip and palate, Oral hygiene, Salivary microflora, cleft lip, cleft palate, comparative study, complication, cross-sectional study, dental caries, female, human, male, microbiology, preschool child, prevalence, questionnaire, saliva, Child, Preschool, Cross-Sectional Studies, Humans, Surveys and Questionnaires
National Category
Dentistry
Identifiers
URN: urn:nbn:se:hj:diva-42394DOI: 10.1007/s40368-018-0326-zISI: 000424649900006PubMedID: 29392531Scopus ID: 2-s2.0-85044588721Local ID: HHJOralISOAI: oai:DiVA.org:hj-42394DiVA, id: diva2:1273773
Funder
Medical Research Council of Southeast Sweden (FORSS)Futurum - Academy for Health and Care, Jönköping County Council, SwedenAvailable from: 2018-12-21 Created: 2018-12-21 Last updated: 2019-02-18Bibliographically approved

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