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Salivary cortisol rhythms in children with cleft lip and/or palate: A case-control study
Jönköping University, School of Health and Welfare, HHJ. Oral health. Department of Pediatric Dentistry, Institute for Postgraduate Dental Education, Jönköping, Sweden.
Department of Dentofacial Orthopedics, Maxillofacial Unit, Linköping University, Linköping, Sweden.
Department of Pediatrics, Skaraborg Hospital, Skövde, Sweden.
2018 (English)In: The Cleft Palate-Craniofacial Journal, ISSN 1055-6656, E-ISSN 1545-1569, Vol. 55, no 8, p. 1072-1080Article in journal (Refereed) Published
Abstract [en]

OBJECTIVE: Knowledge about the stress response in children with cleft lip and/or palate (CL/P) is sparse and the association between the stress response and health-related quality of life (HRQoL) is unknown. Consequently, investigations on the influence of CL/P on the stress response alone and its association with HRQoL are of importance. The purpose was to determine whether salivary cortisol concentration in children with CL/P differs from that in children without clefts (controls) and whether there are any differences in salivary cortisol concentrations between ages, gender, and type of cleft. Furthermore, the final aim was to determine the correlation between salivary cortisol concentration and HRQoL.

DESIGN: The study used a cross-sectional case-control design.

PARTICIPANTS: Ninety-one 5- and 10-year-old children with CL/P and 180 age-matched controls.

MAIN OUTCOME MEASURES: Salivary samples were collected on 2 mornings and 1 evening for each child. Samples were analyzed using a commercial competitive radioimmunoassay and HRQoL was assessed using the KIDSCREEN-52.

RESULTS: Salivary cortisol concentrations were similar in children with CL/P and controls. There was no difference in salivary cortisol concentrations between children with different types of cleft. There was no correlation between cortisol concentration and HRQoL.

CONCLUSION: Five- and 10-year-old children with corrected CL/P seemed not to be more stressed than controls, and there were no correlation to HRQoL. The HRQoL levels - were comparable to that of a European norm population.

Place, publisher, year, edition, pages
Sage Publications, 2018. Vol. 55, no 8, p. 1072-1080
Keywords [en]
children, cleft lip and/or palate, cortisol in saliva, health-related quality of life, stress
National Category
Dentistry
Identifiers
URN: urn:nbn:se:hj:diva-42391DOI: 10.1177/1055665618767425ISI: 000445004200004PubMedID: 29613838Scopus ID: 2-s2.0-85055567090OAI: oai:DiVA.org:hj-42391DiVA, id: diva2:1273695
Funder
Medical Research Council of Southeast Sweden (FORSS)Futurum - Academy for Health and Care, Jönköping County Council, SwedenAvailable from: 2018-12-21 Created: 2018-12-21 Last updated: 2019-01-23Bibliographically approved

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