Endocardial border delineation capability of a multimodal polymer-shelled contrast agentShow others and affiliations
2014 (English)Conference paper, Poster (with or without abstract) (Other academic)
Abstract [en]
Background
A novel polymer-shelled contrast agent (CA) with high mechanical and chemical stability was recently developed [1]. In excess to its ultrasound properties, it also supports targeted and multimodal imaging [2-4]. Even though these new possibilities have the potential to lead to new methodologies and approaches for non-invasive diagnosis, it is important that the fundamental diagnostic features in contrast-enhanced ultrasound are preserved. The aim of this study was therefore to examine the clinical use of the polymer-shelled CA by analyzing the left ventricular endocardial border delineation capability in a porcine model. In addition, physiological effects due to CA injections were studied.
Methods
The endocardial border delineation capability was assessed in a comparative study, which included three doses (1.5 ml, 3 ml and 5 ml, [5x108 MBs/ml]) of the polymer-shelled CA and the commercially available CA SonoVue® (1.5 ml, [2-5x108 MBs/ml]). Ultrasound images of the left ventricle were evaluated manually by blinded observers (n=3) according to a 6-segment model, in which each segment was graded as 0=not visible, 1=barely visible or 2=well visible, as well as semi-automatically by a segmentation software. Furthermore, duration of clinically useful contrast enhancement and changes in physiological parameters were evaluated.
Results
For the highest dose of the polymer-shelled CA, the obtained segment scores, time for clinically sufficient contrast enhancement and semi-automatic delineation capability were comparable to SonoVue®. Moreover, neither dose of the polymer-shelled CA did affect the physiological parameters.
Conclusion
This study demonstrated that the polymer-shelled CA can be used in contrast-enhanced diagnostic imaging without influence on major physiological parameters.
Place, publisher, year, edition, pages
2014.
National Category
Medical Image Processing
Identifiers
URN: urn:nbn:se:hj:diva-42170OAI: oai:DiVA.org:hj-42170DiVA, id: diva2:1267042
Conference
19th European Symposium on Ultrasound Contrast Imaging 23-24 January, 2014, Rotterdam, The Netherlands
2018-11-302018-11-302018-11-30Bibliographically approved