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Endocardial border delineation capability of a multimodal polymer-shelled contrast agent
KTH Royal Institute of Technology, Stockholm, Sweden.
KTH Royal Institute of Technology, Stockholm, Sweden and Karolinska Institutet, Solna, Sweden.
Karolinska Institutet, Stockholm, Sweden.
Università di Roma Tor Vergata, Rome, Italy.
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2014 (English)Conference paper, Poster (with or without abstract) (Other academic)
Abstract [en]

Background

A novel polymer-shelled contrast agent (CA) with high mechanical and chemical stability was recently developed [1]. In excess to its ultrasound properties, it also supports targeted and multimodal imaging [2-4]. Even though these new possibilities have the potential to lead to new methodologies and approaches for non-invasive diagnosis, it is important that the fundamental diagnostic features in contrast-enhanced ultrasound are preserved. The aim of this study was therefore to examine the clinical use of the polymer-shelled CA by analyzing the left ventricular endocardial border delineation capability in a porcine model. In addition, physiological effects due to CA injections were studied.

Methods

The endocardial border delineation capability was assessed in a comparative study, which included three doses (1.5 ml, 3 ml and 5 ml, [5x108 MBs/ml]) of the polymer-shelled CA and the commercially available CA SonoVue® (1.5 ml, [2-5x108 MBs/ml]). Ultrasound images of the left ventricle were evaluated manually by blinded observers (n=3) according to a 6-segment model, in which each segment was graded as 0=not visible, 1=barely visible or 2=well visible, as well as semi-automatically by a segmentation software. Furthermore, duration of clinically useful contrast enhancement and changes in physiological parameters were evaluated.

Results

For the highest dose of the polymer-shelled CA, the obtained segment scores, time for clinically sufficient contrast enhancement and semi-automatic delineation capability were comparable to SonoVue®. Moreover, neither dose of the polymer-shelled CA did affect the physiological parameters.

Conclusion

This study demonstrated that the polymer-shelled CA can be used in contrast-enhanced diagnostic imaging without influence on major physiological parameters.

Place, publisher, year, edition, pages
2014.
National Category
Medical Image Processing
Identifiers
URN: urn:nbn:se:hj:diva-42170OAI: oai:DiVA.org:hj-42170DiVA, id: diva2:1267042
Conference
19th European Symposium on Ultrasound Contrast Imaging 23-24 January, 2014, Rotterdam, The Netherlands
Available from: 2018-11-30 Created: 2018-11-30 Last updated: 2018-11-30Bibliographically approved

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  • apa
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