Background: Occupational therapy has long-standing practices in psychiatry. Nowadays, occupational therapists need appropriate tools and methods for assessment and intervention. People who suffer from depression are one of the patient groups which might have lost their normal routine and performance in life. Aim: To review the literature on practices of occupational therapy in psychiatry with adults suffering from depression Methods: The study design was a systematic review. Databases that were used were AMED, CINAHL, Cochrane Library, ERIC, MEDLINE, PsycINFO, and PuBMED. The handling of the data started by dividing the articles into three categories: assessment tools, methods and approaches, and activities. These categories were formulated with the deductive content analysis. Nineteen articles were identified that met inclusion criteria. Findings: Standardized and non-standardized assessment tools were used. Most of these tools were based on Model of Human Occupation. Activities, used in occupational therapy, included often creative methods. Identified methods and approaches were group interventions, investigating patient’s life span, and multidisciplinary approaches. The majority of selected articles were of low to moderate quality and of low levels of evidence. Conclusions: Information gained is more descriptive rather than scientifically significant evidence of the different practices. More high quality evidence is needed.