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Healthy dietary changes in midlife are associated with reduced dementia risk later in life
Division of Clinical Geriatrics, Center for Alzheimer Research, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden.
Jönköping University, School of Health and Welfare, HHJ, Institute of Gerontology. Jönköping University, School of Health and Welfare, HHJ. ARN-J (Aging Research Network - Jönköping). Aging Research Center, Karolinska Institutet and Stockholm University, Stockholm, Sweden.ORCID iD: 0000-0002-8617-0355
Institute of Clinical Medicine, Department of Neurology, University of Eastern Finland, Kuopio, Finland.
Division of Clinical Geriatrics, Center for Alzheimer Research, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden.
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2018 (English)In: Nutrients, ISSN 2072-6643, E-ISSN 2072-6643, Vol. 10, no 11, article id 1649Article in journal (Refereed) Published
Abstract [en]

Diet is an important modifiable lifestyle factor related to dementia risk. Yet, the role of midlife dietary changes is unclear. The goal is to investigate whether midlife healthy dietary changes are associated with late-life dementia risk. Data were collected within the Cardiovascular Risk Factors, Aging, and Dementia (CAIDE) population-based cohort study (n = 2000) (mean baseline age = 56 years). Participants returned for two late-life re-examinations (mean age = 70 and 78 years). Self-reported midlife diet was measured in a sub-sample (n = 341) (mean total follow-up = 16.8 years). Changes in specific dietary components (fats, vegetables, sugar, salt) were measured in midlife. Dementia diagnoses were ascertained with detailed examinations. Analyses adjusted for potential confounders. Total midlife healthy dietary changes (improving quality of fats, increasing vegetables, decreasing sugar and salt) were associated with a reduced risk of dementia (fully adjusted odds ratio (OR) 0.41, 95% confidence interval (CI) = 0.20–0.85). In contrast, when each factor was assessed individually, associations were not significant. This study is the first to show that beneficial midlife dietary changes are associated with a reduced dementia risk later in life. The results highlight the importance of targeting dietary patterns, where various food items may have synergistic effects. 

Place, publisher, year, edition, pages
MDPI, 2018. Vol. 10, no 11, article id 1649
Keywords [en]
Dementia, Diet, Dietary change, Midlife protective factors, Public health
National Category
Nutrition and Dietetics Neurology
Identifiers
URN: urn:nbn:se:hj:diva-42099DOI: 10.3390/nu10111649ISI: 000451547700087PubMedID: 30400288Scopus ID: 2-s2.0-85056095071Local ID: HHJARNISOAI: oai:DiVA.org:hj-42099DiVA, id: diva2:1264688
Available from: 2018-11-21 Created: 2018-11-21 Last updated: 2018-12-17Bibliographically approved

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