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Apolipoprotein E ε4 genotype and the temporal relationship between depression and dementia
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.ORCID iD: 0000-0003-3605-7829
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2015 (English)In: Neurobiology of Aging, ISSN 0197-4580, E-ISSN 1558-1497, Vol. 36, no 4, p. 1751-1756Article in journal (Refereed) Published
Abstract [en]

To investigate how apolipoprotein E (. APOE) affects the temporal relationship between depression and dementia, we conducted a nested case-control study with longitudinal depression and dementia evaluations from several population studies by using 804 dementia cases and 1600 matched controls, totaling 1519 unique individuals. Depression within 10 years of onset of dementia was strongly associated with dementia diagnosis regardless of APOE status (incidence rate ratio [IRR] 5.25, 95% confidence interval [95% CI] 3.32-8.31 for ε4 carriers, IRR 4.40, 95%CI 3.23-5.99 for noncarriers). However, we found a significant interaction between depression more than 10 years before the onset of dementia and APOE (. p= 0.01), with depression more distal to dementia being a risk factor only in ε4 carriers (IRR 3.39, 95% CI 1.69-6.78 for carriers, IRR 1.01, 95% CI 0.60-1.70 for noncarriers). Thus, depression with onset close in time to dementia onset is associated with disease irrespective of APOE genotype, whereas depression more distal to dementia onset is a risk factor only in ε4-carriers. This is the first study to show the interaction between APOE and depression to be dependent on timing of depression onset.

Place, publisher, year, edition, pages
Elsevier, 2015. Vol. 36, no 4, p. 1751-1756
Keywords [en]
Alzheimer disease, Apolipoprotein e, Dementia, Depression, apolipoprotein E4, adult, aged, Article, case control study, controlled study, disease association, female, gene interaction, genetic risk, genotype, heterozygote, human, incidence, major clinical study, male, onset age, priority journal, genetic association study, genetics, longitudinal study, risk factor, time factor, very elderly, Aged, 80 and over, Case-Control Studies, Genetic Association Studies, Humans, Longitudinal Studies, Risk Factors, Time Factors
National Category
Neurology
Identifiers
URN: urn:nbn:se:hj:diva-41597DOI: 10.1016/j.neurobiolaging.2015.01.008ISI: 000355095300016PubMedID: 25670333Scopus ID: 2-s2.0-84925297197OAI: oai:DiVA.org:hj-41597DiVA, id: diva2:1251197
Available from: 2018-09-26 Created: 2018-09-26 Last updated: 2018-09-26Bibliographically approved

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