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Sleep disturbances and later cognitive status: a multi-centre study
Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden.
Institute of Neuroscience and Physiology, Center for Health and Ageing AGECAP, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Institute of Neuroscience and Physiology, Center for Health and Ageing AGECAP, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden.
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2018 (English)In: Sleep Medicine, ISSN 1389-9457, E-ISSN 1878-5506, Vol. 52, p. 26-33, article id S1389-9457(17)31603-9Article in journal (Refereed) Published
Abstract [en]

OBJECTIVE: To investigate the associations between sleep disturbances in mid-life and late-life and late-life cognitive status.

METHODS: In four population-based studies (three Swedish studies: H70 study, Kungsholmen Project (KP) and The Swedish Panel Study of Living Conditions of the Oldest Old (SWEOLD); and one Finnish study: Cardiovascular Risk Factors, Aging and Dementia (CAIDE)), participants provided self-reports on insomnia, nightmares and general sleep problems. Late-life cognitive status was measured by the Mini Mental State Exam (MMSE). The associations between late-life sleep disturbances and cognition 3-11 years later were investigated across all studies (n = 3210). Mean baseline ages were 70 (CAIDE, H70 and SWEOLD), and 84 years (KP). Additional analyses examined the association between midlife sleep and late-life cognition using CAIDE (21 and 31 years follow-up, n = 1306, mean age 50 years), and SWEOLD (20-24 years follow-up, n = 2068, mean age 58 years). Ordered logistic regressions, adjusted for potential baseline confounders, were used in the analyses.

RESULTS: Late-life sleep disturbances were associated with poorer cognition after 3-11 years (fully adjusted β = -0.12, 95% CI = -0.24 to -0.01). Midlife nightmares and insomnia were also associated with lower MMSE scores (fully adjusted β = -0.28, 95% CI = -0.49 to -0.07 and β = -0.20, 95% CI = -0.39 to -0.01), although the latter association was attenuated after adjusting for lifestyle/health-related confounders. Midlife general sleep problems were not associated with late-life MMSE performance.

CONCLUSIONS: Sleep disturbances and midlife nightmares were associated with lower MMSE scores, which suggests that sleep disturbances in earlier life stages can be associated with worse late-life cognition.

Place, publisher, year, edition, pages
Elsevier, 2018. Vol. 52, p. 26-33, article id S1389-9457(17)31603-9
Keywords [en]
Cognition, Cognitive status, Insomnia, Nightmares, Sleep disturbances
National Category
Gerontology, specialising in Medical and Health Sciences Neurology
Identifiers
URN: urn:nbn:se:hj:diva-41569DOI: 10.1016/j.sleep.2017.11.1149ISI: 000450326800006PubMedID: 30216820Scopus ID: 2-s2.0-85053074787Local ID: HHJARNISOAI: oai:DiVA.org:hj-41569DiVA, id: diva2:1250908
Available from: 2018-09-25 Created: 2018-09-25 Last updated: 2018-12-06Bibliographically approved

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