This study examines the key factors that are associated with the geography of economic segregation across US metros. It connects the sociological literature on the extent and variation of economic segregation to the urban economics literature on the factors associated with urban and regional performance. It advances the hypothesis that economic segregation will be greater in larger, denser, more knowledge-based regions as well as in light of racial factors and income inequality. It utilizes measures of Income, Educational, and Occupational Segregation along with a combined measure of Overall Economic Segregation. Our findings are in line with the hypothesis and indicate that economic segregation is associated with larger, denser, more highly educated metros. Economic segregation is also to a certain extent related with race and ethnicity, commuting style, and income inequality.