Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
BDNF Val66Met and childhood adversity on response to physical exercise and internet-based cognitive behavioural therapy in depressed Swedish adults
Department of Public Health Sciences, Karolinska Institutet, Stockholm, Sweden.
Neurogenetics Unit, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.
Department of Public Health Sciences, Karolinska Institutet, Stockholm, Sweden.ORCID iD: 0000-0003-2733-4441
Department of Public Health Sciences, Karolinska Institutet, Stockholm, Sweden.
Show others and affiliations
2017 (English)In: Journal of Psychiatric Research, ISSN 0022-3956, E-ISSN 1879-1379, Vol. 93, p. 50-58Article in journal (Refereed) Published
Abstract [en]

The genetic effect of Brain-derived neurotrophic factor (BDNF) on treatment response in depression is not consistent in the literature. Childhood adversity is a known risk factor for depression which has been reported to increase depression susceptibility by interacting with BDNF genetic variation. We aimed to explore whether the BDNF variation Val66Met and childhood adversity (CA) predicted the treatment response to a 12-week intervention with physical exercise (PE) or internet-based cognitive behavioural therapy (ICBT) when compared with treatment as usual (TAU). A prospective cohort study nested within a randomised control trial was conducted using data from 547 participants with mild to moderate depression. Depression severity at baseline and follow-up was measured using the Montgomery-Åsberg Depression Rating Scale. Met allele carriers without exposure to CA and current antidepressant use showed higher treatment response to PE than Val homozygotes. There was no evidence to support that BDNF Val66Met or CA alone predicted treatment response to PE and ICBT. The Met carriers had higher serum mature BDNF level. These data suggest that Met allele carriers benefit more from PE treatment but only if they are not exposed to early adversity. 

Place, publisher, year, edition, pages
Elsevier, 2017. Vol. 93, p. 50-58
Keywords [en]
Childhood adversity, Cognitive therapy, Depression, Exercise, Gene-environment interactions, Neurotrophic factor, antidepressant agent, brain derived neurotrophic factor, methionine, valine, adult, allele, Article, childhood disease, cognitive behavioral therapy, cohort analysis, comparative study, controlled study, disease severity, female, follow up, genotype, homozygote, human, Internet, major clinical study, male, Montgomery Asberg Depression Rating Scale, outcome assessment, priority journal, prospective study, randomized controlled trial, Swedish citizen, treatment response, adolescent, child abuse, epidemiology, genetic polymorphism, genetics, metabolism, middle aged, nonparametric test, physiology, procedures, psychology, statistical model, Sweden, Brain-Derived Neurotrophic Factor, Cohort Studies, Humans, Logistic Models, Polymorphism, Genetic, Statistics, Nonparametric
National Category
Psychiatry
Identifiers
URN: urn:nbn:se:hj:diva-39962DOI: 10.1016/j.jpsychires.2017.05.007ISI: 000404708900006PubMedID: 28578208Scopus ID: 2-s2.0-85020001135OAI: oai:DiVA.org:hj-39962DiVA, id: diva2:1214979
Available from: 2018-06-07 Created: 2018-06-07 Last updated: 2018-06-07Bibliographically approved

Open Access in DiVA

No full text in DiVA

Other links

Publisher's full textPubMedScopus

Authority records BETA

Zeebari, Zangin

Search in DiVA

By author/editor
Zeebari, Zangin
In the same journal
Journal of Psychiatric Research
Psychiatry

Search outside of DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 10 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf