BDNF Val66Met and childhood adversity on response to physical exercise and internet-based cognitive behavioural therapy in depressed Swedish adultsShow others and affiliations
2017 (English)In: Journal of Psychiatric Research, ISSN 0022-3956, E-ISSN 1879-1379, Vol. 93, p. 50-58Article in journal (Refereed) Published
Abstract [en]
The genetic effect of Brain-derived neurotrophic factor (BDNF) on treatment response in depression is not consistent in the literature. Childhood adversity is a known risk factor for depression which has been reported to increase depression susceptibility by interacting with BDNF genetic variation. We aimed to explore whether the BDNF variation Val66Met and childhood adversity (CA) predicted the treatment response to a 12-week intervention with physical exercise (PE) or internet-based cognitive behavioural therapy (ICBT) when compared with treatment as usual (TAU). A prospective cohort study nested within a randomised control trial was conducted using data from 547 participants with mild to moderate depression. Depression severity at baseline and follow-up was measured using the Montgomery-Åsberg Depression Rating Scale. Met allele carriers without exposure to CA and current antidepressant use showed higher treatment response to PE than Val homozygotes. There was no evidence to support that BDNF Val66Met or CA alone predicted treatment response to PE and ICBT. The Met carriers had higher serum mature BDNF level. These data suggest that Met allele carriers benefit more from PE treatment but only if they are not exposed to early adversity.
Place, publisher, year, edition, pages
Elsevier, 2017. Vol. 93, p. 50-58
Keywords [en]
Childhood adversity, Cognitive therapy, Depression, Exercise, Gene-environment interactions, Neurotrophic factor, antidepressant agent, brain derived neurotrophic factor, methionine, valine, adult, allele, Article, childhood disease, cognitive behavioral therapy, cohort analysis, comparative study, controlled study, disease severity, female, follow up, genotype, homozygote, human, Internet, major clinical study, male, Montgomery Asberg Depression Rating Scale, outcome assessment, priority journal, prospective study, randomized controlled trial, Swedish citizen, treatment response, adolescent, child abuse, epidemiology, genetic polymorphism, genetics, metabolism, middle aged, nonparametric test, physiology, procedures, psychology, statistical model, Sweden, Brain-Derived Neurotrophic Factor, Cohort Studies, Humans, Logistic Models, Polymorphism, Genetic, Statistics, Nonparametric
National Category
Psychiatry
Identifiers
URN: urn:nbn:se:hj:diva-39962DOI: 10.1016/j.jpsychires.2017.05.007ISI: 000404708900006PubMedID: 28578208Scopus ID: 2-s2.0-85020001135OAI: oai:DiVA.org:hj-39962DiVA, id: diva2:1214979
2018-06-072018-06-072018-06-07Bibliographically approved