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Physical exercise and internet-based cognitive-behavioural therapy in the treatment of depression: Randomised controlled trial
Department of Public Health Sciences, Section for Epidemiology and Public Health Intervention Research (EPHIR), Karolinska Institutet, Stockholm, Sweden.
Department of Clinical Neuroscience, Division of Psychiatry, Karolinska Institutet, Stockholm, Sweden.
Department of Clinical Science, Lund, Division of Psychiatry, Lund University, Lund, Sweden.
Department of Clinical Neuroscience, Division of Psychiatry, Karolinska Institutet, Stockholm, Sweden.
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2015 (English)In: British Journal of Psychiatry, ISSN 0007-1250, E-ISSN 1472-1465, Vol. 207, no 3, p. 227-234Article in journal (Refereed) Published
Abstract [en]

Background

Depression is common and tends to be recurrent. Alternative treatments are needed that are non-stigmatising, accessible and can be prescribed by general medical practitioners.

Aims

To compare the effectiveness of three interventions for depression: physical exercise, internet-based cognitive-behavioural therapy (ICBT) and treatment as usual (TAU). A secondary aim was to assess changes in self-rated work capacity.

Method

A total of 946 patients diagnosed with mild to moderate depression were recruited through primary healthcare centres across Sweden and randomly assigned to one of three 12-week interventions (trail registry: KCTR study ID: KT20110063). Patients were reassessed at 3 months (response rate 78%).

Results

Patients in the exercise and ICBT groups reported larger improvements in depressive symptoms compared with TAU. Work capacity improved over time in all three groups (no significant differences).

Conclusions

Exercise and ICBT were more effective than TAU by a general medical practitioner, and both represent promising non-stigmatising treatment alternatives for patients with mild to moderate depression. 

Place, publisher, year, edition, pages
Cambridge University Press, 2015. Vol. 207, no 3, p. 227-234
Keywords [en]
adult, aged, alcohol consumption, anxiety disorder, Article, cognitive therapy, comparative effectiveness, controlled study, depression, disease severity, exercise, female, follow up, human, intermethod comparison, Internet, internet based cognitive behavioural therapy, job performance, major clinical study, male, Montgomery Asberg Depression Rating Scale, mood disorder, outcome assessment, primary health care, randomized controlled trial, sex difference, Sweden, treatment response, work capacity, adolescent, clinical trial, comparative study, Depressive Disorder, employment, kinesiotherapy, middle aged, multicenter study, multimodality cancer therapy, procedures, self concept, statistics and numerical data, treatment outcome, young adult, Combined Modality Therapy, Exercise Therapy, Humans, Self Efficacy, Work Capacity Evaluation
National Category
Psychiatry
Identifiers
URN: urn:nbn:se:hj:diva-39969DOI: 10.1192/bjp.bp.114.160101ISI: 000361080900009PubMedID: 26089305Scopus ID: 2-s2.0-84938957671OAI: oai:DiVA.org:hj-39969DiVA, id: diva2:1214860
Available from: 2018-06-07 Created: 2018-06-07 Last updated: 2018-06-07Bibliographically approved

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Zeebari, Zangin

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