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Genome-wide linkage scan for breast cancer susceptibility loci in Swedish hereditary non-BRCA1/2 families: Suggestive linkage to 10q23.32-q25.3
Department of Clinical Genetics, Sahlgrenska Academy, Göteborg University, Göteborg, Sweden.
Department of Oncology, Sahlgrenska Academy, Göteborg University, Göteborg, Sweden.
Department of Clinical Genetics, Sahlgrenska Academy, Göteborg University, Göteborg, Sweden.
Department of Clinical Genetics, Sahlgrenska Academy, Göteborg University, Göteborg, Sweden.
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2007 (English)In: Genes, Chromosomes and Cancer, ISSN 1045-2257, E-ISSN 1098-2264, Vol. 46, no 3, p. 302-309Article in journal (Refereed) Published
Abstract [en]

The two breast cancer genes BRCA1 and BRCA2 were identified more than 10 years ago and, depending on population, mutations in these genes are responsible for a varying percentage of familial breast cancer. In more than half the families, the increased risk of breast cancer cannot be explained by mutations in these genes, and the goal of this study was to locate novel susceptibility genes. One of the main difficulties in identifying the cause of hereditary non-BRCA1/BRCA2 breast cancer is genetic heterogeneity, possibly due to multiple, incompletely penetrant susceptibility genes, along with ethnic and geographic differences. In this study, one large family and 13 small to medium-sized families with multiple cases of breast cancer were analyzed by genome-wide linkage analysis. The genome scan was performed by genotype analysis of 10,000 SNP markers on microarrays. The strongest evidence of linkage (HLOD 2.34) was obtained on chromosome region 10q23.32-q25.3. A further two regions were identified, with LOD scores above 2.10 on 12q14-q21 and 19p13.3-q12. In a subset of families of western Swedish origin, two regions generated LOD scores exceeding 1.8: 10q23.32-q25.3 and 19q13.12-q13.32. The large family in the study exceeded LOD 1.5 in three regions: 10q23.32-q25.3, 19q13.12-q13.32, and 17p13. Our results indicate that one or more of the suggested regions may harbor genes that are involved in the development of breast cancer. 

Place, publisher, year, edition, pages
John Wiley & Sons, 2007. Vol. 46, no 3, p. 302-309
Keywords [en]
BRCA1 protein, BRCA2 protein, article, breast cancer, cancer genetics, cancer research, cancer susceptibility, chromosome 10q, chromosome 12q, chromosome 17p, chromosome 19p, chromosome 19q, clinical article, ethnicity, female, gene identification, gene mutation, genetic heterogeneity, genetic linkage, genetic susceptibility, genome analysis, genotype, geographic distribution, heredity, human, marker gene, microarray analysis, oncogene, population genetics, priority journal, single nucleotide polymorphism, Sweden, tumor suppressor gene, Breast Neoplasms, Chromosomes, Human, Pair 10, European Continental Ancestry Group, Genes, BRCA1, Genes, BRCA2, Genome, Human, Humans, Linkage (Genetics), Polymorphism, Single Nucleotide
National Category
Cancer and Oncology
Identifiers
URN: urn:nbn:se:hj:diva-39623DOI: 10.1002/gcc.20405ISI: 000243443300009PubMedID: 17171685Scopus ID: 2-s2.0-33846526637OAI: oai:DiVA.org:hj-39623DiVA, id: diva2:1211719
Available from: 2018-05-31 Created: 2018-05-31 Last updated: 2018-05-31Bibliographically approved

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