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Job strain and atrial fibrillation – Results from the Swedish Longitudinal Occupational Survey of Health and meta-analysis of three studies
Jönköping University, School of Health and Welfare, HHJ, Dep. of Natural Science and Biomedicine. Jönköping University, School of Health and Welfare, HHJ. ADULT. Department of Psychology, Umeå University, Sweden.ORCID iD: 0000-0001-9042-4832
Umeå Universitet.
Stockholms universitet.
Stockholms universitet.
2018 (English)In: European Journal of Preventive Cardiology, ISSN 2047-4873, E-ISSN 2047-4881Article in journal (Refereed) Epub ahead of print
Abstract [en]

Background

Knowledge about the impact of occupational exposures, such as work stress, on the risk of atrial fibrillation is limited. The present study aims to investigate the association between job strain, a measure of work stress, and atrial fibrillation.

Design

Prospective cohort study design and fixed-effect meta-analysis.

Methods

Data from the Swedish Longitudinal Occupational Survey of Health (SLOSH) was utilised for the main analysis, combining self-reported data on work stress at baseline with follow-up data on atrial fibrillation from nationwide registers. Cox proportional hazard regression analyses were used to estimate hazard ratios and 95% confidence intervals (CIs). A fixed-effect meta-analysis was conducted to pool the results from the present study with results from two similar previously published studies.

Results

Based on SLOSH data, job strain was associated with an almost 50% increased risk of atrial fibrillation (hazard ratio 1.48, 95% CI 1.00–2.18) after adjustment for age, sex and education. Further adjustment for smoking, physical activity, body mass index and hypertension did not alter the estimated risk. The meta-analysis of the present and two previously published studies showed a consistent pattern, with job strain being associated with increased risk of atrial fibrillation in all three studies. The estimated pooled hazard ratio was 1.37 (95% CI 1.13–1.67).

Conclusion

The results highlight that occupational exposures, such as work stress, may be important risk factors for incident atrial fibrillation.

Place, publisher, year, edition, pages
Sage Publications, 2018.
Keywords [en]
Atrial fibrillation, work, stress, psychological, risk factors, cohort study
National Category
Public Health, Global Health, Social Medicine and Epidemiology
Identifiers
URN: urn:nbn:se:hj:diva-39441DOI: 10.1177/2047487318777387PubMedID: 29846118Scopus ID: 2-s2.0-85047929687OAI: oai:DiVA.org:hj-39441DiVA, id: diva2:1205997
Available from: 2018-05-15 Created: 2018-05-15 Last updated: 2018-07-05

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