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Adding high-intensity interval training to conventional training modalities: optimizing health-related outcomes during chemotherapy for breast cancer: the OptiTrain randomized controlled trial
Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden / Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Huddinge, Sweden.
Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Huddinge, Sweden / Theme Cancer, Karolinska University Hospital, Stockholm, Sweden.
Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Huddinge, Sweden / School of Human Movement and Nutrition Sciences, The University of Queensland, Brisbane, Australia.
Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Huddinge, Sweden.
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2018 (English)In: Breast Cancer Research and Treatment, ISSN 0167-6806, E-ISSN 1573-7217, Vol. 168, no 1, p. 79-93Article in journal (Refereed) Published
Abstract [en]

PURPOSE: Exercise training is an effective and safe way to counteract cancer-related fatigue (CRF) and to improve health-related quality of life (HRQoL). High-intensity interval training has proven beneficial for the health of clinical populations. The aim of this randomized controlled trial was to compare the effects of resistance and high-intensity interval training (RT-HIIT), and moderate-intensity aerobic and high-intensity interval training (AT-HIIT) to usual care (UC) in women with breast cancer undergoing chemotherapy. The primary endpoint was CRF and the secondary endpoints were HRQoL and cancer treatment-related symptoms.

METHODS: Two hundred and forty women planned to undergo chemotherapy were randomized to supervised RT-HIIT, AT-HIIT, or UC. Measurements were performed at baseline and at 16 weeks. Questionnaires included Piper Fatigue Scale, EORTC-QLQ-C30, and Memorial Symptom Assessment Scale.

RESULTS: The RT-HIIT group was superior to UC for CRF: total CRF (p = 0.02), behavior/daily life (p = 0.01), and sensory/physical (p = 0.03) CRF. Role functioning significantly improved while cognitive functioning was unchanged for RT-HIIT compared to declines shown in the UC group (p = 0.04). AT-HIIT significantly improved emotional functioning versus UC (p = 0.01) and was superior to UC for pain symptoms (p = 0.03). RT-HIIT reported a reduced symptom burden, while AT-HIIT remained stable compared to deteriorations shown by UC (p < 0.01). Only RT-HIIT was superior to UC for total symptoms (p < 0.01).

CONCLUSIONS: 16 weeks of resistance and HIIT was effective in preventing increases in CRF and in reducing symptom burden for patients during chemotherapy for breast cancer. These findings add to a growing body of evidence supporting the inclusion of structured exercise prescriptions, including HIIT, as a vital component of cancer rehabilitation.

TRIAL REGISTRATION: Clinicaltrials.gov Registration Number: NCT02522260.

Place, publisher, year, edition, pages
Springer, 2018. Vol. 168, no 1, p. 79-93
Keywords [en]
Breast cancer, Chemotherapy, Concurrent training, Health-related quality of life, High-intensity interval training, Symptom burden
National Category
Clinical Medicine
Research subject
Wellbeing in long-term health problems (WeLHP)
Identifiers
URN: urn:nbn:se:hj:diva-39224DOI: 10.1007/s10549-017-4571-3ISI: 000425747200009PubMedID: 29139007Scopus ID: 2-s2.0-85033731943OAI: oai:DiVA.org:hj-39224DiVA, id: diva2:1201746
Available from: 2018-03-29 Created: 2018-04-26Bibliographically approved

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