Electronic medical records (EMR) have been implemented in developed countries since 1972 when the first computer-stored medical record at Wishard Memorial Hospital was designed. However, less seem to be known about EMRs in an African context. The purpose of this paper is therefore to review studies on EMRs implemented in sub-Saharan Africa and to identify benefits and challenges met. Articles available in PubMed, PMC, Scopus, JAMIA and Google were searched through JIBS online library using the search string "EMR systems in Sub-Saharan Africa". In most the papers, EMRs have been implemented in HIV/AIDS settings allowing better monitoring of patients under antiretroviral therapy (ART). EMR systems have also succeeded to increase the number of patients under ART. Moreover, EMRs have improved work processes as they have reduced patients waiting time and enhanced monitoring of medical appointments. However, EMRs have suffered lack of electricity, poor Internet connectivity and computer illiteracy. Today, HIV/AIDS care providers have benefited on the implementation of EMRs and there is a possibility to extend the implementation to other healthcare departments.