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Imaging Predictors of Improvement from a Motor Learning-Based Intervention for Children with Unilateral Cerebral Palsy
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2016 (English)In: Neurorehabilitation and Neural Repair, ISSN 1545-9683, E-ISSN 1552-6844, Vol. 30, no 7, 647-660 p.Article in journal (Refereed) Published
Abstract [en]

Background:

Motor-learning interventions may improve hand function in children with unilateral cerebral palsy (UCP) but with inconsistent outcomes across participants. Objective. To examine if pre-intervention brain imaging predicts benefit from bimanual intervention.

Method:

Twenty children with UCP with Manual Ability Classification System levels I to III, aged 7-16 years, participated in an intensive bimanual intervention. Assessments included the Assisting Hand Assessment (AHA), Jebsen Taylor Test of Hand Function (JTTHF) and Children's Hand Experience Questionnaire (CHEQ) at baseline (T1), completion (T2) and 8-10 weeks post-intervention (T3). Imaging at baseline included conventional structural (radiological score), functional (fMRI) and diffusion tensor imaging (DTI).

Results:

Improvements were seen across assessments; AHA (P = 0.04), JTTHF (P <.001) and CHEQ (P < 0.001). Radiological score significantly correlated with improvement at T2; AHA (r =.475) and CHEQ (r =.632), but negatively with improvement on unimanual measures at T3 (JTTFH r = -.514). fMRI showed negative correlations between contralesional brain activation when moving the affected hand and AHA improvements (T2: r = -.562, T3: r = -0.479). Fractional Anisotropy in the affected posterior limb of the internal capsule correlated negatively with increased bimanual use on CHEQ at T2 (r = -547) and AHA at T3 (r = -.656).

Conclusions:

Children with greater structural, functional and connective brain damage showed enhanced responses to bimanual intervention. Baseline imaging may identify parameters predicting response to intervention in children with UCP.

Place, publisher, year, edition, pages
Sage Publications, 2016. Vol. 30, no 7, 647-660 p.
Keyword [en]
DTI, fMRI, prediction, treatment, unilateral cerebral palsy, adolescent, Article, Assisting Hand Assessment, brain injury, capsula interna, cerebral palsy, child, childhood disease, Children's Hand Experience Questionnaire, clinical article, corpus callosum, diffusion tensor imaging, female, follow up, fractional anisotropy, functional magnetic resonance imaging, functional neuroimaging, functional status assessment, hand function, human, International Classification of Functioning, Disability and Health, intervention study, Jebsen Taylor Test of Hand Function, male, school child, sensorimotor cortex, task performance, treatment response, white matter, clinical trial, diagnostic imaging, disability, hand, hemispheric dominance, image processing, movement (physiology), multicenter study, musculoskeletal manipulation, neuroimaging, pathophysiology, physiology, procedures, psychomotor performance, questionnaire, Disability Evaluation, Functional Laterality, Humans, Image Processing, Computer-Assisted, Movement, Musculoskeletal Manipulations, Surveys and Questionnaires
National Category
Neurology
Identifiers
URN: urn:nbn:se:hj:diva-37444DOI: 10.1177/1545968315613446ISI: 000380937600005PubMedID: 26564999Scopus ID: 2-s2.0-84978101025OAI: oai:DiVA.org:hj-37444DiVA: diva2:1146042
Available from: 2017-10-02 Created: 2017-10-02 Last updated: 2017-10-02Bibliographically approved

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Green, Dido

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