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A Kinetic Overview of the Receptors Involved in 1,25-Dihydroxyvitamin D3 and 24,25-Dihydroxyvitamin D3 Signaling: A Systems Biology Approach
Högskolan i Skövde, Forskningscentrum för Systembiologi.
Högskolan i Skövde, Forskningscentrum för Systembiologi.
Högskolan i Skövde, Forskningscentrum för Systembiologi.ORCID iD: 0000-0002-4724-0269
2009 (English)In: Critical Reviews in Eukaryotic Gene Expression, ISSN 1045-4403, E-ISSN 2162-6502, Vol. 19, no 3, p. 181-196Article, review/survey (Refereed) Published
Abstract [en]

The vitamin D endocrine system modulates an arsenal of important biological functions in more than 30 different tissues in short- and long-term perspectives. Two membrane receptors and one nuclear receptor are suggested to be involved in the vitamin D signaling system, but the function and physiological relevance of the receptors are debated. The complexity of the vitamin D endocrine system makes it necessary to combine experimental data with in silico simulations to get a holistic view of vitamin D-dependent regulation of tissue and cell physiology. This review focus on binding characteristics for the three putative vitamin D receptors and proposes a future systems biology approach including mathematical modeling that will be helpful together with experimental methods in depicting antitumoral and other biological effects promoted by the vitamin D endocrine system.

Place, publisher, year, edition, pages
Begell House, 2009. Vol. 19, no 3, p. 181-196
Keywords [en]
vitamin D, mathematical modeling, nVDR, PDIA3, catalase, receptor kinetics
National Category
Biochemistry and Molecular Biology
Research subject
Natural sciences
Identifiers
URN: urn:nbn:se:hj:diva-37356DOI: 10.1615/CritRevEukarGeneExpr.v19.i3.20ISI: 000270313600003PubMedID: 19883364Scopus ID: 2-s2.0-67650314922OAI: oai:DiVA.org:hj-37356DiVA, id: diva2:1142832
Available from: 2009-12-01 Created: 2017-09-20Bibliographically approved

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