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Baseline telomere length and effects of a multidomain lifestyle intervention on cognition: The FINGER randomized controlled trial
Aging Research Center, Karolinska Institutet and Stockholm University, Stockholm, Sweden.
Division of Clinical Geriatrics, Center for Alzheimer Research, Karolinska Institutet, Stockholm, Sweden.
Department of Biosciences, University of Helsinki, Helsinki, Finland.
Jönköping University, School of Health and Welfare, HHJ, Institute of Gerontology. Jönköping University, School of Health and Welfare, HHJ. ARN-J (Aging Research Network - Jönköping). Aging Research Center, Karolinska Institutet and Stockholm University, Stockholm, Sweden.
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2017 (English)In: Journal of Alzheimer's Disease, ISSN 1387-2877, E-ISSN 1875-8908, Vol. 59, no 4, 1459-1470 p.Article in journal (Refereed) Published
Abstract [en]

Leukocyte telomere length (LTL) is a biomarker of aging, and it is associated with lifestyle. It is currently unknown whether LTL is associated with the response to lifestyle interventions. The goal is to assess whether baseline LTL modified the cognitive benefits of a 2-year multidomain lifestyle intervention (exploratory analyses). The Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) was a 2-year randomized controlled trial including 1,260 people at risk of cognitive decline, aged 60-77 years identified from the general population. Participants were randomly assigned to the lifestyle intervention (diet, exercise, cognitive training, and vascular risk management) and control (general health advice) groups. Primary outcome was change in cognition (comprehensive neuropsychological test battery). Secondary outcomes were changes in cognitive domains: Memory, executive functioning, and processing speed. 775 participants (392 control, 383 intervention) had baseline LTL (peripheral blood DNA). Mixed effects regression models with maximum likelihood estimation were used to analyze change in cognition as a function of randomization group, time, baseline LTL, and their interaction. Intervention and control groups did not significantly differ at baseline. Shorter LTL was related to less healthy baseline lifestyle. Intervention benefits on executive functioning were more pronounced among those with shorter baseline LTL (p-value for interaction was 0.010 adjusted for age and sex, and 0.007 additionally adjusted for baseline lifestyle factors). The FINGER intervention cognitive benefits were more pronounced with shorter baseline LTL, particularly for executive functioning, indicating that the multidomain lifestyle intervention was especially beneficial among higher-risk individuals.

Place, publisher, year, edition, pages
IOS Press, 2017. Vol. 59, no 4, 1459-1470 p.
Keyword [en]
Cognition, dementia, lifestyle, multidomain intervention, telomere length
National Category
Geriatrics
Identifiers
URN: urn:nbn:se:hj:diva-37182DOI: 10.3233/JAD-170123ISI: XYZPubMedID: 28777749Scopus ID: 2-s2.0-85027534844Local ID: HHJARNISOAI: oai:DiVA.org:hj-37182DiVA: diva2:1138359
Available from: 2017-09-05 Created: 2017-09-05 Last updated: 2017-09-05Bibliographically approved

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Kåreholt, Ingemar

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