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Subclinical white matter lesions and medial temporal lobe atrophy are associated with EEG slowing in a memory clinic cohort.
Department of Neurology, University Medical Centre, Ljubljana, Slovenia.
Department of Neurophysiology, Karolinska University Hospital, Stockholm, Sweden.
Department of Radiology, Karolinska University Hospital, Stockholm, Sweden.
Jönköping University, School of Health and Welfare, HHJ, Institute of Gerontology. Jönköping University, School of Health and Welfare, HHJ. ARN-J (Aging Research Network - Jönköping). Aging Research Center, Karolinska Institutet and Stockholm University, Stockholm, Sweden.ORCID iD: 0000-0002-8617-0355
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2017 (English)In: Clinical Neurophysiology, ISSN 1388-2457, E-ISSN 1872-8952, Vol. 128, no 9, 1575-1582 p., S1388-2457(17)30214-6Article in journal (Refereed) Published
Abstract [en]

OBJECTIVE: The aim of the study was to describe the relationship between electroencephalographic (EEG) findings obtained by standardized visual analysis, subclinical white matter lesions (WML) and brain atrophy in a large memory clinic population.

METHODS: Patients with Alzheimer's disease (AD, n=58), mild cognitive impairment (MCI, n=141), subjective cognitive impairment (SCI, n=194) had clinical, MRI based WML severity and regional atrophy assessments, and routine resting EEG recording. Background activity (BA) and episodic and continuous abnormalities were assessed visually in EEG.

RESULTS: WML (p=0.006) and atrophy in medial temporal regions (MTA) (p=<0.001) were associated with slower BA in all diagnoses. WML were associated in SCI with total episodic EEG abnormalities (p=0.03).

CONCLUSIONS: EEG is associated with subclinical WML burden and cortical brain atrophy in a memory clinic population.

SIGNIFICANCE: Even the standard visually assessed EEG can complement a memory clinic diagnostic workup.

Place, publisher, year, edition, pages
Elsevier, 2017. Vol. 128, no 9, 1575-1582 p., S1388-2457(17)30214-6
Keyword [en]
Cognitive impairment, Electroencephalography, Medial temporal atrophy, Visual analysis, White matter lesions
National Category
Neurology
Identifiers
URN: urn:nbn:se:hj:diva-37179DOI: 10.1016/j.clinph.2017.05.018ISI: 000415742000006PubMedID: 28709123Scopus ID: 2-s2.0-85022198367Local ID: HHJÅldrandeISOAI: oai:DiVA.org:hj-37179DiVA: diva2:1138289
Available from: 2017-09-04 Created: 2017-09-04 Last updated: 2017-12-28Bibliographically approved

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Kåreholt, Ingemar

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