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Investigation of the elimination process of a multimodal polymer-shelled contrast agent in rats using ultrasound and transmission electron microscopy
KTH, Strukturell bioteknik.ORCID iD: 0000-0002-9604-0511
KTH, Medicinsk bildteknik.ORCID iD: 0000-0002-4757-7232
KTH, Strukturell bioteknik.ORCID iD: 0000-0002-0569-3374
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2015 (English)In: Biomedical Spectroscopy and Imaging, ISSN 2212-8794, Vol. 4, no 1, 81-93 p.Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: A novel polymer-shelled contrast agent (CA) with multimodal imaging and target specific potential was developed recently and tested for its acoustical properties using different in-vitro setups.

OBJECTIVE: The aim of this study was to investigate the elimination of three types of the novel polymer-shelled CA, one unmodified and two shell modified versions, in rats.

METHODS: The blood elimination time was estimated by measuring the image intensity, from ultrasound images of the common carotid artery, over time after a bolus injection of the three types of the novel CA. The commercially available CA SonoVue was used as a reference. The subcellular localization of the three CAs was investigated using transmission electron microscopy.

RESULTS: The ultrasound measurements indicated a blood half-life of 17–85 s for the different types of the novel CA, which was significant longer than the blood half-life time for SonoVue. Additionally, CAs were exclusively found in the circulatory system, either taken up by, or found in the vicinity of macrophages.

CONCLUSIONS: Compared to the commercially available CA SonoVue, the blood circulation times for the three types of the novel polymer-shelled CA were prolonged. Moreover, macrophages were suggested to be responsible for the elimination of the CA.

Place, publisher, year, edition, pages
2015. Vol. 4, no 1, 81-93 p.
Keyword [en]
Contrast agent, polymer, subcellular localization, transmission electron microscope, ultrasound imaging
National Category
Medical Engineering
Research subject
Medical Technology
Identifiers
URN: urn:nbn:se:hj:diva-37077DOI: 10.3233/BSI-140099OAI: oai:DiVA.org:hj-37077DiVA: diva2:1137435
Funder
EU, FP7, Seventh Framework Programme, 245572]
Available from: 2015-03-03 Created: 2017-08-31Bibliographically approved

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Härmark, JohanLarsson, Malin K.Koeck, Philip JBHebert, HansBjällmark, Anna
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CiteExportLink to record
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Citation style
  • apa
  • harvard1
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