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Påverkan på subpopulationer av CD4+ och CD8+ T-celler hos unga vuxna som upplevt psykisk stress vid olika livsskeden
Jönköping University, School of Health and Welfare, HHJ. Biomedical Platform.
Jönköping University, School of Health and Welfare, HHJ. Biomedical Platform.
2017 (Swedish)Independent thesis Basic level (degree of Bachelor), 180 HE creditsStudent thesisAlternative title
Impact on subpopulations of CD4+ and CD8+ T cells in young adults who experienced psychological stress at different lifespan (English)
Abstract [sv]

Exponering av psykisk stress kan förändra immunförsvaret. Syftet med studien var att undersöka hur psykisk stress vid olika livsskeden, påverkar subpopulationer av T-celler hos unga vuxna. Blodprov insamlades från unga vuxna (18–22 år, 29 kvinnor och 16 män) som upplevt psykisk stress samt unga vuxna (18–22 år, 16 kvinnor och 10 män) som inte upplevt psykisk stress. Subpopulationer av CD4+ T-hjälpar (Th)-celler och CD8+ cytotoxiska T (Tc)celler som naïva celler, centrala minnesceller (TCM), effektor minnesceller (TEM), sent differentierade effektor minnesceller (TEM-late) och terminalt differentierade effektor minnesceller (TEMRA) studerades med flödescytometri. Upplevd psykisk stress under barndomen visade en ökad andel ThCM-celler hos kvinnor och naïva Th- och Tc-celler hos män. Kvinnor som upplevt en stressfylld livshändelse visade en ökad andel ThEM-late-celler och kvinnor som upplevt en stressfylld livshändelse och stress under senaste månaden visade en ökad andel naïva Th-celler och en minskad andel ThEM-celler. Resultaten som erhölls indikerade på att psykisk stress under barndomen gav en påverkan hos båda könen, och att kvinnorna blev mer påverkade av psykisk stress än männen. Resultaten tolkades som suggestiva, och framtida studier bör omfatta ett större urval för mer tillförlitliga resultat.

Abstract [en]

Exposure of psychological stress may alter the immune system. The aim of the study was to investigate how psychological stress at different lifespans, affect subpopulations of T-cells in young adults of both genders. Blood samples were collected from young adults (18-22 years, 29 women and 16 men) who had experienced psychological stress, and young adults (18-22 years, 16 women and 10 men) who had not experienced psychological stress. Subpopulations of CD4+ T-helper (Th)-cells and CD8+ cytotoxic-T (Tc)-cells such as naïve cells, central memory (TCM)-, effector memory (TEM)-, late differentiated effector memory (TEM-late) and terminally differentiated effector memory (TEMRA)-cells were studied by flow cytometry. Experienced childhood maltreatment showed increased percentage of ThCM-cells in women, and increased percentage of naïve Th- and Tc-cells in men. Women who experienced a stressful life event showed increased percentage of ThEM-late-cells, and women who experienced a stressful life event and experienced stress in the past month showed increased percentage of naïve Th-cells and decreased percentage of ThEM-cells. The results indicated that childhood maltreatment affect both genders, and that women are more affected by psychological stress. The findings should be interpreted as suggestive, and future studies should be conducted on larger study populations for more reliable results.

Place, publisher, year, edition, pages
2017. , 24 p.
Keyword [en]
psychological stress, immune system, CD4+ T-helper cell, CD8+ cytotoxic-T cell, flow cytometry
Keyword [sv]
psykisk stress, immunförsvar, CD4+ T-hjälpar cell, CD8+ cytotoxisk T-cell, flödescytometri
National Category
Natural Sciences Immunology
Identifiers
URN: urn:nbn:se:hj:diva-36210ISRN: JU-HHJ-BLA-1-20170037OAI: oai:DiVA.org:hj-36210DiVA: diva2:1111162
Subject / course
HHJ, Biomedical Laboratory Science
Presentation
2017-06-05, Jönköping, 16:00
Supervisors
Examiners
Projects
Impact of Stress
Available from: 2017-06-19 Created: 2017-06-17 Last updated: 2017-06-19Bibliographically approved

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Påverkan på subpopulationer av CD4+ och CD8+ T-celler hos unga vuxna som upplevt psykisk stress vid olika livsskeden(586 kB)140 downloads
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Citation style
  • apa
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