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Screening of circulating microRNA biomarkers for prevalence of abdominal aortic aneurysm and aneurysm growth
Uppsala University, Sweden.
Uppsala University, Sweden.
Linköping University, Sweden.
Jönköping University, School of Health and Welfare, HHJ, Dep. of Natural Science and Biomedicine. Jönköping University, School of Health and Welfare, HHJ. ADULT. Division of Medical Diagnostics, Department of Clinical Physiology, Region Jönköping County, Sweden.ORCID iD: 0000-0003-3802-9661
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2017 (English)In: Atherosclerosis, ISSN 0021-9150, E-ISSN 1879-1484, Vol. 256, 82-88 p.Article in journal (Refereed) Published
Abstract [en]

Background and aims

MicroRNA (miR) are important regulators of gene expression and biological processes and have recently been suggested as possible biomarkers for abdominal aortic aneurysm (AAA) disease. The aim of the present study was to assess the role of miR as biomarkers for initiation and progression of AAA disease, through evaluation of a wide range of miRs in a large population-based cohort, with AAA patients with linked clinical data regarding risk factors, AAA size and growth, as well as controls.

Methods

The expression of the 172 most commonly expressed miRs in plasma was analyzed by real-time PCR in samples from 169 screening-detected AAA patients and 48 age-matched controls.

Results

For 103 miRs, there was a significant difference in expression between AAA and controls. Of these, 20 miRs were differently expressed between fast and slow growing aneurysms. These miRs target genes known to be involved in AAA disease as well as novel genes and pathways. By combining the top altered miRs together with clinical variables, strong predictive values, determining growth of AAA, were obtained (area under curve = 0.86, p < 0.001).

Conclusions

This large cohort study identified several novel miRs with altered expression in AAA patients when compared to controls. Assessment of miR expression may offer an opportunity to predict disease progression and aneurysm growth.

Place, publisher, year, edition, pages
Elsevier, 2017. Vol. 256, 82-88 p.
Keyword [en]
Biomarker, Plasma, Risk factor, Aneurysm, MicroRNA
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:hj:diva-34761DOI: 10.1016/j.atherosclerosis.2016.11.007ISI: 000393891900012PubMedID: 27993388Scopus ID: 2-s2.0-85008191091OAI: oai:DiVA.org:hj-34761DiVA: diva2:1066225
Available from: 2017-01-17 Created: 2017-01-17 Last updated: 2017-11-29Bibliographically approved

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De Basso, Rachel

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