Pharmaceutical companies function in complex, heavily regulated markets characterized by declining access to physicians, limited customer loyalty, downward pricing pressure and low levels of public trust. The communication with key influencers requires above-average creativity and knowledge, and old, analogue patterns of communication in the new digital world are not an effective option anymore. Building on the fundamental ideas of Web 2.0, this paper deals with Web 2.0-oriented solutions for pharmaceutical companies. New communication landscape requires pharmaceutical companies to rethink the communication logic, which will help them to reach out to key influencers.