Ändra sökning
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Association between sleep characteristics and incident dementia accounting for baseline cognitive status: A prospective population-based study
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Högskolan i Jönköping, Hälsohögskolan, HHJ, Institutet för gerontologi. Högskolan i Jönköping, Hälsohögskolan, HHJ. ARN-J (Aging Research Network - Jönköping). Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.ORCID-id: 0000-0002-6305-8993
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Visa övriga samt affilieringar
2017 (Engelska)Ingår i: The journals of gerontology. Series A, Biological sciences and medical sciences, ISSN 1079-5006, E-ISSN 1758-535X, Vol. 72, nr 1, s. 134-139Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Background: While research has shown that sleep disorders are prevalent among people with dementia, the temporal relationship is unclear. We investigated whether atypical sleep characteristics were associated with incident dementia while accounting for baseline cognitive functioning.

Methods: Screening Across the Lifespan Twin Study (SALT) participants were 11,247 individuals from the Swedish Twin Registry who were at least 65 years at baseline (1998-2002). Sleep and baseline cognitive functioning were assessed via the SALT telephone screening interview. Data on dementia diagnoses came from national health registers. Cox regression was performed to estimate hazard ratios (HR) for dementia.

Results: After 17 years of follow-up, 1,850 dementia cases were identified. Short (≤ 6 hours) and extended (> 9 hours) time-in-bed (TIB) compared to the middle reference group (HR=1.40, 95% CI=1.06-1.85, HR=1.11, 95% CI=1.00-1.24, respectively) and rising at 8:00AM or later compared to earlier rising (HR=1.12, 95% CI=1.01-1.24) were associated with higher dementia incidence. Bedtime, sleep quality, restorative sleep, and heavy snoring were not significant predictors. Findings stratified by baseline cognitive status indicated that the association between short TIB and dementia remained in those cognitively intact at the start.

Conclusions: Short and extended TIB as well as delayed rising among older adults predicted increased dementia incidence in the following 17 years. The pattern of findings suggests that extended TIB and late rising represent prodromal features whereas short TIB appeared to be a risk factor for dementia.

Ort, förlag, år, upplaga, sidor
Oxford University Press, 2017. Vol. 72, nr 1, s. 134-139
Nyckelord [en]
Dementia, cognitive impairment, incidence, sleep characteristics, prodromal sign, risk factor
Nationell ämneskategori
Gerontologi, medicinsk/hälsovetenskaplig inriktning
Identifikatorer
URN: urn:nbn:se:hj:diva-30922DOI: 10.1093/gerona/glw127ISI: 000396948200019PubMedID: 27402049Scopus ID: 2-s2.0-85014730987Lokalt ID: HHJARNISOAI: oai:DiVA.org:hj-30922DiVA, id: diva2:943898
Tillgänglig från: 2016-06-28 Skapad: 2016-06-28 Senast uppdaterad: 2018-01-10Bibliografiskt granskad

Open Access i DiVA

Fulltext(444 kB)64 nedladdningar
Filinformation
Filnamn FULLTEXT01.pdfFilstorlek 444 kBChecksumma SHA-512
a1ebb423e3612e56e433d84d4b13b84ca069d054ea7c61b99e72bcd390819ffa32d00e6d3e047c60091113b002c466b0936381e9de5440e0633356f499b48440
Typ fulltextMimetyp application/pdf

Övriga länkar

Förlagets fulltextPubMedScopus

Personposter BETA

Dahl Aslan, Anna K.

Sök vidare i DiVA

Av författaren/redaktören
Dahl Aslan, Anna K.
Av organisationen
HHJ, Institutet för gerontologiHHJ. ARN-J (Aging Research Network - Jönköping)
I samma tidskrift
The journals of gerontology. Series A, Biological sciences and medical sciences
Gerontologi, medicinsk/hälsovetenskaplig inriktning

Sök vidare utanför DiVA

GoogleGoogle Scholar
Totalt: 64 nedladdningar
Antalet nedladdningar är summan av nedladdningar för alla fulltexter. Det kan inkludera t.ex tidigare versioner som nu inte längre är tillgängliga.

doi
pubmed
urn-nbn

Altmetricpoäng

doi
pubmed
urn-nbn
Totalt: 328 träffar
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf