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Gender-Specific Association of the Plasminogen Activator Inhibitor-1 4G/5G Polymorphism With Central Arterial Blood Pressure
Linköping University.
Karolinska Institutet.
Linköping University.
Linköping University.
Vise andre og tillknytning
2011 (engelsk)Inngår i: American Journal of Hypertension, ISSN 0895-7061, E-ISSN 1941-7225, Vol. 24, nr 7, s. 802-808Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

BACKGROUND The functional plasminogen activator inhibitor-1 (PAI-1) 4G/5G polymorphism has previously been associated with hypertension. In recent years, central blood pressure, rather than brachial has been argued a better measure of cardiovascular damage and clinical outcome. The aim of this study was to investigate the possible influence of the 4G/5G polymorphism on central arterial blood pressure in a cohort of elderly individuals.

METHODS We studied 410 individuals, 216 men and 194 women, aged 70-88. Central pressures and pulse waveforms were calculated from the radial artery pressure waveform by the use of the SphygmoCor system and a generalized transfer function. Brachial pressure was recorded using oscillometric technique (Dinamap, Critikon, Tampa, FL). PAI-1 antigen was determined in plasma.

RESULTS The results showed that central pressures were higher in women carrying the PAI-1 4G/4G genotype compared to female carriers of the 5G/5G genotype, (P = 0.025, P = 0.002, and P = 0.002 for central systolic-, diastolic-, and mean arterial pressure, respectively). The association remained after adjustment for potentially confounding factors related to hypertension. No association of the PAI-1 genotype with blood pressure was found in men. Multiple regression analysis revealed an association between PAI-1 genotype and plasma PAI-1 levels (P = 0.048).

CONCLUSIONS Our findings show a gender-specific association of the PAI-1 4G/5G polymorphism with central arterial blood pressure. The genotype effect was independent of other risk factors related to hypertension, suggesting that impaired fibrinolytic potential may play an important role in the development of central hypertension in women.

sted, utgiver, år, opplag, sider
2011. Vol. 24, nr 7, s. 802-808
Emneord [en]
aorta, arterial stiffness, blood pressure, genetics, hypertension, pressure pulse wave
HSV kategori
Identifikatorer
URN: urn:nbn:se:hj:diva-28381DOI: 10.1038/ajh.2011.63ISI: 000291901100014PubMedID: 21490692OAI: oai:DiVA.org:hj-28381DiVA, id: diva2:873864
Tilgjengelig fra: 2015-11-25 Laget: 2015-11-25 Sist oppdatert: 2017-12-01bibliografisk kontrollert

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