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Apoptotic neutrophils containing Staphylococcus epidermidis stimulate macrophages to release the proinflammatory cytokines tumor necrosis factor-α and interleukin-6
Jönköping University, School of Health and Welfare, HHJ, Dep. of Natural Science and Biomedicine.
Division of Medical Microbiology, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linköping University, Linköping, Sweden.
Division of Medical Microbiology, Linköping University, Linköping, Sweden; and Division of Infectious Diseases, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linköping University, Linköping, Sweden.
Division of Infectious Diseases, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linköping University, Linköping, Sweden.
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2008 (English)In: FEMS Immunology and Medical Microbiology, ISSN 0928-8244, E-ISSN 1574-695X, Vol. 53, no 1, p. 126-135Article in journal (Refereed) Published
Abstract [en]

Staphylococcus epidermidis infections are usually nosocomial and involve colonization of biomaterials. The immune defense system cannot efficiently control the bacteria during these infections, which often results in protracted chronic inflammation, in which a key event is disturbed removal of neutrophils by tissue macrophages. While ingesting uninfected apoptotic neutrophils, macrophages release anti-inflammatory cytokines that lead to resolution of inflammation. In clinical studies, we have previously found elevated levels of the proinflammatory cytokines tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 in synovial fluid from prostheses infected with coagulase negative staphylococci. We show that macrophages phagocytosing apoptotic neutrophils containing S. epidermidis released TNF-alpha and interleukin-6, whereas macrophages phagocytosing spontaneously apoptotic neutrophils did not. This difference was not due to dissimilar phagocytic capacities, because macrophages ingested both types of neutrophils to the same extent. The activation was induced mainly by the apoptotic neutrophils themselves, not by the few remaining extracellular bacteria. Macrophages were not activated by apoptotic neutrophils that contained paraformaldehyde-killed S. epidermidis. Proinflammatory reactions induced by clearance of apoptotic neutrophils containing S. epidermidis might represent an important mechanism to combat the infective agent. This activation of macrophages may contribute to the development of chronic inflammation instead of inflammation resolution.

Place, publisher, year, edition, pages
Oxford University Press, 2008. Vol. 53, no 1, p. 126-135
Keywords [en]
Staphylococcus epidermidis infection; neutrophil; macrophage; chronic inflammation; phagocytosis; TNF-α; TNF-alpha
National Category
Immunology
Identifiers
URN: urn:nbn:se:hj:diva-5576DOI: 10.1111/j.1574-695X.2008.00412.xISI: 000255644300016PubMedID: 18400011Scopus ID: 2-s2.0-43349091469OAI: oai:DiVA.org:hj-5576DiVA, id: diva2:36396
Available from: 2008-05-09 Created: 2008-05-09 Last updated: 2019-08-30Bibliographically approved

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