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Stability of Genetic Influences on Pulmonary Function in a Longitudinal Study of Octogenarian Twins
Department of Biobehavioral Health, The Pennsylvania State University.
Department of Biobehavioral Health, The Pennsylvania State University.
Jönköping University, School of Health Science, HHJ, Institute of Gerontology. Jönköping University, School of Health Science, HHJ. Ageing - living conditions and health.
Jönköping University, School of Health Science, HHJ, Institute of Gerontology. Jönköping University, School of Health Science, HHJ. Ageing - living conditions and health.
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2010 (English)In: American Journal of Human Biology, ISSN 1042-0533, E-ISSN 1520-6300, Vol. 22, no 3, p. 375-377Article in journal (Refereed) Published
Abstract [en]

Using data from the first four waves of the OCTO-Twin study (twins 80 + years), the present study investigated the stability and change of genetic and environmental contributions to pulmonary function. Using a genetic simplex model, variance in peak expiratory flow (PEF) at each wave was decomposed into additive genetic and nonshared (specific) environmental factors. Additionally, this analysis distinguished the source of these influences, either from previous waves (transmissions) or from novel influences at each wave (innovations). At each time point (except wave 1), the genetic variance was due to genetic transmissions from prior time points. Conversely, the specific environmental variance in PEF at each time point was mainly due to environmental innovations. These results imply that genetic factors contribute to the stability of pulmonary function over time whereas environmental factors contribute to its change.

Place, publisher, year, edition, pages
2010. Vol. 22, no 3, p. 375-377
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Biological Sciences
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URN: urn:nbn:se:hj:diva-11230DOI: 10.1002/ajhb.21003PubMedID: 19844901OAI: oai:DiVA.org:hj-11230DiVA, id: diva2:283823
Available from: 2009-12-30 Created: 2009-12-30 Last updated: 2017-12-12Bibliographically approved

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