Despite the recent proliferation of research on blockchain, the existing literature is widely dispersed and lacks a comprehensive understanding of the integration of blockchain in impacting environmental and social sustainability. The purpose of our review is to synthesize previous research on the intersection of blockchain and sustainability. In our systematic review, we integrate and reconcile existing research on blockchain and sustainability by presenting antecedents and outcomes of blockchain integration and how blockchain is leveraged to achieve environmental and social impacts. We also propose a future research agenda to advance our knowledge of blockchain’s role in enhancing organizations’ sustainability efforts.