Since the first missions and until today,the aerospace industry has been making significant technological advances and developments,working in the edge of innovation and technology. Despite the considerable advances in this sector,the degree of complexity and the risks associated are inherent to the process. In this sense,the development of safety strategies,including human factors approach,is a way to promote process safety in the design of the projects,construction,operation,and maintenance,in land,air and space. Although NASA had implemented several safety barriers in their operations since its beginning,some major accidents occurred,notably Columbia (2003) and Challenger (1986). At the same time,workplaces in the oil and gas (O&G) industry have evolved to become part of the modern complex sociotechnical system that characterizes onshore and offshore facilities today. The intense interactions between workers,systems,equipment,and processes have made companies in this sector more productive,but significant and complex risks have also emerged. This industry has a history of several accidents,such as Piper Alpha (1988),Texas City Refinery (2005) and Deepwater Horizon (2010),causing heavy losses and global geopolitical changes. All these accidents,in aerospace and O&G industries,involved machines and system that are operating in the very limit of engineering,specially in the sharp end of the operations. Having both industries as background,this study presents a human factor approach to assess two relevant accidents,using the FRAM (Functional Resonance Analysis Method) to perform this analysis.