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Ultrasonographic strain imaging is superior to conventional non-invasive measures of vascular stiffness in the detection of age-dependent differences in the mechanical properties of the common carotid artery
KTH, Medicinsk teknik.ORCID-id: 0000-0002-1188-8098
KTH, Medicinsk teknik.
KTH, Medicinsk teknik.
KTH, Skolan för teknik och hälsa (STH).
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2010 (Engelska)Ingår i: European Journal of Echocardiography, ISSN 1525-2167, E-ISSN 1532-2114, Vol. 11, nr 7, s. 630-636Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Aims: Elastic properties of large arteries have been shown to deteriorate with age and in the presence of atherosclerotic vascular disease. In this study, the performance of ultrasonographic strain measurements was compared to conventional measures of vascular stiffness in the detection of age-dependent differences in the elastic properties of the common carotid artery.

Methods and results: In 10 younger (25-28 years, 4 women) and 10 older (50-59 years, 4 women) healthy individuals, global and regional circumferential and radial strain variables were measured in the short-axis view of the right common carotid artery using ultrasonographic two-dimensional (2D) strain imaging with recently introduced speckle tracking technique. Conventional elasticity variables, elastic modulus (Ep) and β stiffness index, were calculated using M-mode sonography and non-invasive blood pressure measurements. Global and regional circumferential systolic strain and strain rate values were significantly higher (p < 0.001, p < 0.01 for regional late systolic strain rate) in the younger individuals, whereas the values of conventional elasticity variables in the same group were lower (p < 0.05). Among all strain and conventional elasticity variables, principal component analysis and its regression extension identified only circumferential systolic strain variables as contributing significantly to the observed discrimination between the younger and older age groups.

Conclusion: Ultrasonographic 2D-strain imaging is a sensitive method for the assessment of elastic properties in the common carotid artery, being in this respect superior to conventional measures of vascular elasticity. The method has potential to become a valuable non-invasive tool in the detection of early atherosclerotic vascular changes.

Ort, förlag, år, upplaga, sidor
2010. Vol. 11, nr 7, s. 630-636
Nationell ämneskategori
Medicinsk laboratorie- och mätteknik
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URN: urn:nbn:se:hj:diva-37065DOI: 10.1093/ejechocard/jeq033ISI: 000280704100016Scopus ID: 2-s2.0-77955443516OAI: oai:DiVA.org:hj-37065DiVA, id: diva2:1137481
Tillgänglig från: 2009-12-11 Skapad: 2017-08-31 Senast uppdaterad: 2017-11-29Bibliografiskt granskad

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