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Physical Activity, Blood Glucose and C-Peptide in Healthy School-Children, a Longitudinal Study
Högskolan i Jönköping, Hälsohögskolan, HHJ, Avd. för omvårdnad. Högskolan i Jönköping, Hälsohögskolan, HHJ. CHILD.ORCID-id: 0000-0003-4599-155X
Linköping University, Sweden.
Linnaeus University and University of Gothenburg, Sweden.
Linköping University and Östergötland County Council, Sweden.
2016 (engelsk)Inngår i: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 11, nr 6, artikkel-id e0156401Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Aim

To further elucidate the relationship between physical activity and several risk factors for development of diabetes (glucose, C-peptide and obesity) over time.

Methods

A prospective longitudinal study where physical activity was measured on 199 children from Kalmar and Linköping at age 8, and the same 107 children from Linköping again at age 12. Anthropometric data was collected and blood was analyzed for C-peptide and f-glucose. The children in the study were representative for the general Swedish child population, and on an average lean.

Results

High physical activity was related to lower C-peptide at age 8 and 12. This correlation was especially pronounced in boys, who also were more physically active than girls at both time points. The association seen at 8 years of age was similar at age 12 in most children. Children with higher BMI Z-Score had a higher fasting C-peptide (age 12) but linear regression showed that children with more steps per day were less likely to have a higher fasting C-peptide irrespective of BMI. Longitudinal follow-up showed that a decrease in physical activity increased insulin resistance and β-cell load.

Conclusions

Already in young children, physical activity improves insulin sensitivity and decreases the need of C-peptide over time. This seems to become even more pronounced with increasing age when children are followed longitudinally. Low physical activity increases the load on insulin producing β-cells, might increase the risk for both type 1- and 2 diabetes.

sted, utgiver, år, opplag, sider
2016. Vol. 11, nr 6, artikkel-id e0156401
HSV kategori
Identifikatorer
URN: urn:nbn:se:hj:diva-34138DOI: 10.1371/journal.pone.0156401ISI: 000377561000012PubMedID: 27270732Scopus ID: 2-s2.0-84975221785OAI: oai:DiVA.org:hj-34138DiVA, id: diva2:1051016
Tilgjengelig fra: 2016-11-30 Laget: 2016-11-30 Sist oppdatert: 2017-11-29bibliografisk kontrollert

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