Endre søk
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
CAIDE Dementia Risk Score and biomarkers of neurodegeneration in memory clinic patients without dementia
Department of Neurobiology, Care Sciences and Society, Division of Neurogeriatrics, Karolinska Institutet, Stockholm, Sweden.
Department of Neurobiology, Care Sciences and Society, Division of Neurogeriatrics, Karolinska Institutet, Stockholm, Sweden, and Institute of Clinical Medicine/Neurology, University of Eastern Finland, Kuopio, Finland.
Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden.
Högskolan i Jönköping, Hälsohögskolan, HHJ, Institutet för gerontologi. Högskolan i Jönköping, Hälsohögskolan, HHJ. ARN-J (Aging Research Network - Jönköping). Department of Neurobiology, Care Sciences and Society, Aging Research Center, Karolinska Institutet and Stockholm University, Stockholm, Sweden.ORCID-id: 0000-0002-8617-0355
Vise andre og tillknytning
2016 (engelsk)Inngår i: Neurobiology of Aging, ISSN 0197-4580, E-ISSN 1558-1497, Vol. 42, s. 124-131Artikkel i tidsskrift (Fagfellevurdert) Published
Resurstyp
Text
Abstract [en]

The aim of this study was to explore cross-sectional associations between Cardiovascular Risk Factors, Aging and Dementia Study (CAIDE) Dementia Risk Score and dementia-related cerebrospinal fluid and neuroimaging biomarkers in 724 patients without dementia from the Memory Clinic at Karolinska University Hospital, Huddinge, Sweden. We additionally evaluated the score's capacity to predict dementia. Two risk score versions were calculated: one including age, gender, obesity, hyperlipidemia, and hypertension; and one additionally including apolipoprotein E (APOE) ε4 carrier status. Cerebrospinal fluid was analyzed for amyloid β (Aβ), total tau, and phosphorylated tau. Visual assessments of medial temporal lobe atrophy (MTA), global cortical atrophy-frontal subscale, and Fazekas scale for white matter changes (WMC) were performed. Higher CAIDE Dementia Risk Score (version without APOE) was significantly associated with higher total tau, more severe MTA, WMC, and global cortical atrophy-frontal subscale. Higher CAIDE Dementia Risk Score (version with APOE) was associated with reduced Aβ, more severe MTA, and WMC. CAIDE Dementia Risk Score version with APOE seemed to predict dementia better in this memory clinic population with short follow-up than the version without APOE.

sted, utgiver, år, opplag, sider
2016. Vol. 42, s. 124-131
Emneord [en]
Amyloid beta, CAIDE dementia risk score, Mild cognitive impairment, Neurodegeneration, Subjective cognitive impairment, Tau
HSV kategori
Identifikatorer
URN: urn:nbn:se:hj:diva-29956DOI: 10.1016/j.neurobiolaging.2016.03.007ISI: 000375129500014PubMedID: 27143429Scopus ID: 2-s2.0-84962920586Lokal ID: HHJÅldrandeISOAI: oai:DiVA.org:hj-29956DiVA, id: diva2:929538
Tilgjengelig fra: 2016-05-19 Laget: 2016-05-19 Sist oppdatert: 2018-01-10bibliografisk kontrollert

Open Access i DiVA

Fulltext(331 kB)136 nedlastinger
Filinformasjon
Fil FULLTEXT01.pdfFilstørrelse 331 kBChecksum SHA-512
a7392202d43613ff2fda3a8acdcf481a156b436a91bc67f33965f94b1064dd074f79061ecb1645e837ae8734cc9bd455fdbb7795a2921f0f67da36d651238c71
Type fulltextMimetype application/pdf

Andre lenker

Forlagets fulltekstPubMedScopus

Personposter BETA

Kåreholt, Ingemar

Søk i DiVA

Av forfatter/redaktør
Kåreholt, Ingemar
Av organisasjonen
I samme tidsskrift
Neurobiology of Aging

Søk utenfor DiVA

GoogleGoogle Scholar
Totalt: 136 nedlastinger
Antall nedlastinger er summen av alle nedlastinger av alle fulltekster. Det kan for eksempel være tidligere versjoner som er ikke lenger tilgjengelige

doi
pubmed
urn-nbn

Altmetric

doi
pubmed
urn-nbn
Totalt: 205 treff
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf