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Nitric oxide-dependent mitotic activity in salivary glands of the rat upon sympathetic stimulation
Department of Pharmacology, Sahlgrenska Academy at Göteborg University, Göteborg, Sweden.
Department of Pharmacology, Sahlgrenska Academy Göteborg University, Göteborg, Sweden.
2004 (engelsk)Inngår i: Archives of Oral Biology, ISSN 0003-9969, E-ISSN 1879-1506, Vol. 49, nr 11, s. 889-894Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Incorporation of [3H]thymidine into trichloroacetic acid (TCA)-insoluble material of the parotid and submandibular glands was used as an index of mitotic activity following unilateral electrical stimulation of the sympathetic innervation (20 Hz, 4 min every fifth minute over 34 min). Stimulation under β-adrenoceptor blockade (propranolol 2 mg/kg, intravenous) alone or combined with α-adrenoceptor blockade (phentolamine 2 mg/kg, intravenous) did not increase the rate of [3H]thymidine incorporation into the two types of glands. However, under α-adrenoceptor blockade the [3H]thymidine incorporation increased into the parotid glands, by 122% (compared to the glands on the contralateral side), but not into the submandibular glands. In the presence of the neuronal type NO-synthase (nNOS) blocker N-PLA (30 mg/kg, intravenous) or the unselective NO-synthase blocker L-NAME (30 mg/kg, intravenous), this increase was reduced to 49 and 47%, respectively. Thus, the major part of the sympathetically nerve-evoked β-adrenoceptor-mediated mitotic response was found to depend on the activity of neuronal type NO-synthase to generate NO. Since the sympathetic nerve fibres of the parotid gland lack NO-synthase, the neuronal type NO-synthase subjected to the inhibitors is likely to be of parenchymal origin. © 2004 Elsevier Ltd. All rights reserved.

sted, utgiver, år, opplag, sider
Elsevier, 2004. Vol. 49, nr 11, s. 889-894
Emneord [en]
β-Adrenoceptors, Mitosis, Nitric oxide synthase, Salivary glands, Sympathetic nerve stimulation, alpha adrenergic receptor blocking agent, beta adrenergic receptor blocking agent, nitric oxide, phentolamine, propranolol, adrenergic system, animal, article, cytology, drug effect, electrostimulation, female, innervation, parotid gland, physiology, rat, salivary gland, Sprague Dawley rat, submandibular gland, Adrenergic alpha-Antagonists, Adrenergic beta-Antagonists, Animals, Electric Stimulation, Rats, Rats, Sprague-Dawley, Sympathetic Nervous System
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Identifikatorer
URN: urn:nbn:se:hj:diva-45108DOI: 10.1016/j.archoralbio.2004.04.007ISI: 000224592600005PubMedID: 15353244Scopus ID: 2-s2.0-4444241856OAI: oai:DiVA.org:hj-45108DiVA, id: diva2:1330762
Tilgjengelig fra: 2019-06-26 Laget: 2019-06-26 Sist oppdatert: 2019-06-26bibliografisk kontrollert

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