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Publications (10 of 28) Show all publications
Finkel, D., Franz, C. E., Christensen, K., Reynolds, C. A. & Pedersen, N. L. (2020). Longitudinal twin study of subjective health: Differences in genetic and environmental components of variance across age and sex. The journals of gerontology. Series B, Psychological sciences and social sciences, 75(1), 1-10
Open this publication in new window or tab >>Longitudinal twin study of subjective health: Differences in genetic and environmental components of variance across age and sex
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2020 (English)In: The journals of gerontology. Series B, Psychological sciences and social sciences, ISSN 1079-5014, E-ISSN 1758-5368, Vol. 75, no 1, p. 1-10Article in journal (Refereed) Published
Abstract [en]

Objective: The current analysis examines sex differences in longitudinal changes in genetic and environmental influences on three measures of subjective health.

Method: Sample includes 7372 twins (mean intake age = 73.22) with up to 8 waves of measurement (mean = 3.1). Three subjective health (SH) items were included: general self-rated health (SRH), health compared to age peers (COMP), and impact of health on activities (ACT) which previous research shows capture different frames of reference.

Results: Latent growth curve modeling indicated significant differences across gender and frame of reference in trajectories of change with age and in genetic and environmental contributions to change. Men have higher mean scores on all three SH measures, indicating better SH, but there were no sex differences in pattern of change with age. Accelerating declines with age were found for SRH and ACT, whereas COMP improved with age. Results indicated more genetic variance for women than men, but declining genetic variance for both after age 70. Increasing shared environmental variance with increasing age was also found for both sexes.

Discussion: As aging triggers a re-evaluation of the meaning of "good health," physical aspects of health may become less important and shared cultural conceptions of health may become more relevant. This change in conceptions of good health may reflect both aging and the change in composition of the elderly population as a result of selective survival.

Place, publisher, year, edition, pages
Oxford University Press, 2020
National Category
Gerontology, specialising in Medical and Health Sciences
Identifiers
urn:nbn:se:hj:diva-43119 (URN)10.1093/geronb/gby030 (DOI)29590493 (PubMedID)2-s2.0-85076441728 (Scopus ID)KOA HHJ 2020;HHJARNIS (Local ID)KOA HHJ 2020;HHJARNIS (Archive number)KOA HHJ 2020;HHJARNIS (OAI)
Available from: 2019-02-20 Created: 2019-02-20 Last updated: 2020-01-02Bibliographically approved
Zammit, A. R., Piccinin, A. M., Duggan, E. C., Koval, A., Clouston, S., Robitaille, A., . . . Hofer, S. M. (2019). A coordinated multi-study analysis of the longitudinal association between handgrip strength and cognitive function in older adults.. The journals of gerontology. Series B, Psychological sciences and social sciences, Article ID gbz072.
Open this publication in new window or tab >>A coordinated multi-study analysis of the longitudinal association between handgrip strength and cognitive function in older adults.
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2019 (English)In: The journals of gerontology. Series B, Psychological sciences and social sciences, ISSN 1079-5014, E-ISSN 1758-5368, article id gbz072Article in journal (Refereed) Epub ahead of print
Abstract [en]

OBJECTIVE: Handgrip strength, an indicator of overall muscle strength, has been found to be associated with slower rate of cognitive decline and decreased risk for cognitive impairment and dementia. However, evaluating the replicability of associations between aging-related changes in physical and cognitive functioning is challenging due to differences in study designs and analytical models. A multiple-study coordinated analysis approach was used to generate new longitudinal results based on comparable construct-level measurements and identical statistical models and to facilitate replication and research synthesis.

METHODS: We performed coordinated analysis on nine cohort studies affiliated with the Integrative Analysis of Longitudinal Studies of Aging and Dementia (IALSA) research network. Bivariate linear mixed models were used to examine associations among individual differences in baseline level, rate of change, and occasion-specific variation across grip strength and indicators of cognitive function, including mental status, processing speed, attention and working memory, perceptual reasoning, verbal ability, and learning and memory. Results were summarized using meta-analysis.

RESULTS: After adjustment for covariates, we found an overall moderate association between change in grip strength and change in each cognitive domain for both males and females: Average correlation coefficient was 0.55 (95% CI = 0.44 - 0.56). We also found a high level of heterogeneity in this association across studies.

DISCUSSION: Meta-analytic results from nine longitudinal studies showed consistently positive associations between linear rates of change in grip strength and changes in cognitive functioning. Future work will benefit from the examination of individual patterns of change to understand the heterogeneity in rates of aging and health-related changes across physical and cognitive biomarkers.

Place, publisher, year, edition, pages
Oxford University Press, 2019
Keywords
cognitive function, coordinated analysis, grip strength, harmonization, integrative data analysis, longitudinal studies
National Category
Gerontology, specialising in Medical and Health Sciences
Identifiers
urn:nbn:se:hj:diva-47339 (URN)10.1093/geronb/gbz072 (DOI)31187137 (PubMedID)
Available from: 2020-01-13 Created: 2020-01-13 Last updated: 2020-01-13
Duggan, E. C., Piccinin, A. M., Clouston, S., Koval, A. V., Robitaille, A., Zammit, A. R., . . . Hofer, S. M. (2019). A multi-study coordinated meta-analysis of pulmonary function and cognition in aging. The journals of gerontology. Series A, Biological sciences and medical sciences, 74(11), 1793-1804
Open this publication in new window or tab >>A multi-study coordinated meta-analysis of pulmonary function and cognition in aging
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2019 (English)In: The journals of gerontology. Series A, Biological sciences and medical sciences, ISSN 1079-5006, E-ISSN 1758-535X, Vol. 74, no 11, p. 1793-1804Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Substantial research is dedicated to understanding the aging-related dynamics among individual differences in level, change, and variation across physical and cognitive abilities. Evaluating replicability and synthesizing these findings has been limited by differences in measurements and samples, and by study design and statistical analyses confounding between-person differences with within-person changes. In this paper, we conducted a coordinated analysis and summary meta-analysis of new results on the aging-related dynamics linking pulmonary function and cognitive performance.

METHODS: We performed coordinated analysis of bivariate growth models in data from 20,586 participants across eight longitudinal studies to examine individual differences in baseline level, rate of change, and occasion-specific variability in pulmonary and cognitive functioning. Results were summarized using meta-analysis.

RESULTS: We found consistent but weak baseline and longitudinal associations in levels of pulmonary and cognitive functioning, but no associations in occasion-specific variability.

CONCLUSIONS: Results provide limited evidence for a consistent link between simultaneous changes in pulmonary and cognitive function in a normal aging population. Further research is required to understand patterns of onset of decline and differences in rates of change within and across physical and cognitive functioning domains, both within-individuals and across countries and birth cohorts. Coordinated analysis provides an efficient and rigorous approach for replicating and comparing results across independent longitudinal studies.

Place, publisher, year, edition, pages
Oxford University Press, 2019
Keywords
cognition, cognitive aging, longitudinal analysis, normative aging, pulmonary
National Category
Gerontology, specialising in Medical and Health Sciences
Identifiers
urn:nbn:se:hj:diva-43627 (URN)10.1093/gerona/glz057 (DOI)000491242600014 ()30825374 (PubMedID)2-s2.0-85072942783 (Scopus ID);HHJARNIS (Local ID);HHJARNIS (Archive number);HHJARNIS (OAI)
Available from: 2019-05-09 Created: 2019-05-09 Last updated: 2020-01-14Bibliographically approved
Finkel, D. & Ernsth-Bravell, M. (2019). Age changes in lung function precede and contribute to subsequent age changes in motor function and cognition. In: : . Paper presented at International Conference of Psychological Science, 7-9 March 2019, Paris, France.
Open this publication in new window or tab >>Age changes in lung function precede and contribute to subsequent age changes in motor function and cognition
2019 (English)Conference paper, Oral presentation only (Refereed)
National Category
Gerontology, specialising in Medical and Health Sciences
Identifiers
urn:nbn:se:hj:diva-43624 (URN)
Conference
International Conference of Psychological Science, 7-9 March 2019, Paris, France
Available from: 2019-05-09 Created: 2019-05-09 Last updated: 2019-05-09Bibliographically approved
Finkel, D. & Schwartz, E. (2019). Diversity of day-to-day emotional experiences and social interactions. In: : . Paper presented at International Association of Gerontology and Geriatrics European Region Congress 2019, 23rd – 25th May 2019, Gothenburg, Sweden.
Open this publication in new window or tab >>Diversity of day-to-day emotional experiences and social interactions
2019 (English)Conference paper, Oral presentation with published abstract (Refereed)
National Category
Gerontology, specialising in Medical and Health Sciences
Identifiers
urn:nbn:se:hj:diva-43752 (URN)
Conference
International Association of Gerontology and Geriatrics European Region Congress 2019, 23rd – 25th May 2019, Gothenburg, Sweden
Available from: 2019-05-22 Created: 2019-05-22 Last updated: 2019-05-22Bibliographically approved
Jylhävä, J., Raymond, E., Reynolds, C., Finkel, D., Ericsson, M., Dahl Aslan, A. K., . . . Pedersen, N. (2019). Drivers of frailty from adulthood into old age: Results from a 27-year longitudinal population-based study in Sweden. In: : . Paper presented at International Association of Gerontology and Geriatrics European Region Congress 2019, 23rd – 25th May 2019, Gothenburg, Sweden.
Open this publication in new window or tab >>Drivers of frailty from adulthood into old age: Results from a 27-year longitudinal population-based study in Sweden
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2019 (English)Conference paper, Oral presentation with published abstract (Refereed)
National Category
Gerontology, specialising in Medical and Health Sciences
Identifiers
urn:nbn:se:hj:diva-43737 (URN)
Conference
International Association of Gerontology and Geriatrics European Region Congress 2019, 23rd – 25th May 2019, Gothenburg, Sweden
Available from: 2019-05-22 Created: 2019-05-22 Last updated: 2019-05-22Bibliographically approved
Finkel, D., Emery, C. F., Gatz, M. & Dahl Aslan, A. K. (2019). Evidence of bi-directional associations between depressive symptoms and body mass among older adults. In: : . Paper presented at The annual meeting of the Swedish Society of Epidemiology, Stockholm, Sweden.
Open this publication in new window or tab >>Evidence of bi-directional associations between depressive symptoms and body mass among older adults
2019 (English)Conference paper, Oral presentation only (Other academic)
National Category
Gerontology, specialising in Medical and Health Sciences
Identifiers
urn:nbn:se:hj:diva-43626 (URN)
Conference
The annual meeting of the Swedish Society of Epidemiology, Stockholm, Sweden
Available from: 2019-05-09 Created: 2019-05-09 Last updated: 2019-05-09
Emery, C. F., Finkel, D., Gatz, M. & Dahl Aslan, A. K. (2019). Evidence of bi-directional associations between depressive symptoms and body mass among older adults. The journals of gerontology. Series B, Psychological sciences and social sciences
Open this publication in new window or tab >>Evidence of bi-directional associations between depressive symptoms and body mass among older adults
2019 (English)In: The journals of gerontology. Series B, Psychological sciences and social sciences, ISSN 1079-5014, E-ISSN 1758-5368Article in journal (Refereed) Epub ahead of print
Abstract [en]

OBJECTIVES: Body fat, measured with body mass index (BMI), and obesity are associated with depressive symptoms. Among younger adults there is stronger evidence of obesity leading to depressive symptoms than of depressive symptoms leading to obesity, but the temporal relationship is unknown among older adults. This study utilized dual-change-score models (DCSMs) to determine the directional relationship between body mass and depressive symptoms among older adults.

METHOD: Participants (n=1743) from the Swedish Twin Registry (baseline age range 50-96 years) completed at least one assessment of BMI (nurse measurement of height and weight) and the Center for Epidemiologic Studies-Depression scale (CESD). More than half the sample completed three or more assessments, scheduled at intervals of 2-4 years. DCSMs modeled the relationship of BMI and CESD across age, both independently and as part of bivariate relationships.

RESULTS: Depressive symptoms contributed to subsequent changes in BMI after age 70, while BMI contributed to subsequent changes in depressive symptoms after age 82. Thus, there is a reciprocal relationship that may change with age. The effect was more pronounced for women.

DISCUSSION: The association of BMI and depressive symptoms is bi-directional among older adults, and it appears to be affected by both age and sex.

Place, publisher, year, edition, pages
Oxford University Press, 2019
National Category
Gerontology, specialising in Medical and Health Sciences
Identifiers
urn:nbn:se:hj:diva-43457 (URN)10.1093/geronb/gbz022 (DOI)30843043 (PubMedID);HHJARNIS (Local ID);HHJARNIS (Archive number);HHJARNIS (OAI)
Available from: 2019-04-11 Created: 2019-04-11 Last updated: 2019-04-11
Finkel, D., Sternäng, O., Jylhävä, J., Bai, G. & Pedersen, N. L. (2019). Functional Aging Index Complements Frailty in Prediction of Entry into Care and Mortality.. The journals of gerontology. Series A, Biological sciences and medical sciences, 74(12), 1980-1986
Open this publication in new window or tab >>Functional Aging Index Complements Frailty in Prediction of Entry into Care and Mortality.
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2019 (English)In: The journals of gerontology. Series A, Biological sciences and medical sciences, ISSN 1079-5006, E-ISSN 1758-535X, Vol. 74, no 12, p. 1980-1986Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: The aim was to develop a functional aging index (FAI) that taps four body systems: sensory (vision and hearing), pulmonary, strength (grip strength), and movement/balance (gait speed) and to test the predictive value of FAI for entry into care and mortality.

METHOD: Growth curve models and cox regression models were applied to data from 1695 individuals from three Swedish longitudinal studies of aging. Participants were aged 45 to 93 at intake and data from up to 8 follow-up waves were available.

RESULTS: The rate of change in FAI was twice as fast after age 75 as before, women demonstrated higher mean FAI, but no sex differences in rates of change with chronological age were identified. FAI predicted entry into care and mortality, even when chronological age and a frailty index were included in the models. Hazard ratios indicated FAI was a more important predictor of entry into care for men than women; whereas it was a stronger predictor of mortality for men than women.

CONCLUSIONS: Measures of biological aging and functional aging differ in their predictive value for entry into care and mortality for men and women, suggesting that both are necessary for a complete picture of the aging process across genders.

Place, publisher, year, edition, pages
Oxford University Press, 2019
Keywords
gender, latent growth curve, survival analysis
National Category
Gerontology, specialising in Medical and Health Sciences
Identifiers
urn:nbn:se:hj:diva-44783 (URN)10.1093/gerona/glz155 (DOI)000501737700020 ()31222213 (PubMedID)2-s2.0-85074962916 (Scopus ID)PP HHJ 2019 embargo 12;HHJARNIS (Local ID)PP HHJ 2019 embargo 12;HHJARNIS (Archive number)PP HHJ 2019 embargo 12;HHJARNIS (OAI)
Available from: 2019-06-24 Created: 2019-06-24 Last updated: 2020-01-14Bibliographically approved
Finkel, D. (2019). Genetic and Environmental Influences on Functional Ability in the Second Half of Life. In: : . Paper presented at International Congress “Social Adaptation, Assistance, and Elderly Health in Present-Day Society,” 10-13 April 2019, St. Petersburg, Russia.
Open this publication in new window or tab >>Genetic and Environmental Influences on Functional Ability in the Second Half of Life
2019 (English)Conference paper, Oral presentation with published abstract (Refereed)
National Category
Gerontology, specialising in Medical and Health Sciences
Identifiers
urn:nbn:se:hj:diva-43625 (URN)
Conference
International Congress “Social Adaptation, Assistance, and Elderly Health in Present-Day Society,” 10-13 April 2019, St. Petersburg, Russia
Available from: 2019-05-09 Created: 2019-05-09 Last updated: 2019-05-09Bibliographically approved
Organisations
Identifiers
ORCID iD: ORCID iD iconorcid.org/0000-0003-2346-2470

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