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Wilsson, Åsa
Publications (4 of 4) Show all publications
Wilsson, Å., Lind, S., Öhman, L., Nilsdotter-Augustinsson, Å. & Lundqvist-Setterud, H. (2008). Apoptotic neutrophils containing Staphylococcus epidermidis stimulate macrophages to release the proinflammatory cytokines tumor necrosis factor-α and interleukin-6. FEMS Immunology and Medical Microbiology, 53(1), 126-135
Open this publication in new window or tab >>Apoptotic neutrophils containing Staphylococcus epidermidis stimulate macrophages to release the proinflammatory cytokines tumor necrosis factor-α and interleukin-6
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2008 (English)In: FEMS Immunology and Medical Microbiology, ISSN 0928-8244, E-ISSN 1574-695X, Vol. 53, no 1, p. 126-135Article in journal (Refereed) Published
Abstract [en]

Staphylococcus epidermidis infections are usually nosocomial and involve colonization of biomaterials. The immune defense system cannot efficiently control the bacteria during these infections, which often results in protracted chronic inflammation, in which a key event is disturbed removal of neutrophils by tissue macrophages. While ingesting uninfected apoptotic neutrophils, macrophages release anti-inflammatory cytokines that lead to resolution of inflammation. In clinical studies, we have previously found elevated levels of the proinflammatory cytokines tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 in synovial fluid from prostheses infected with coagulase negative staphylococci. We show that macrophages phagocytosing apoptotic neutrophils containing S. epidermidis released TNF-alpha and interleukin-6, whereas macrophages phagocytosing spontaneously apoptotic neutrophils did not. This difference was not due to dissimilar phagocytic capacities, because macrophages ingested both types of neutrophils to the same extent. The activation was induced mainly by the apoptotic neutrophils themselves, not by the few remaining extracellular bacteria. Macrophages were not activated by apoptotic neutrophils that contained paraformaldehyde-killed S. epidermidis. Proinflammatory reactions induced by clearance of apoptotic neutrophils containing S. epidermidis might represent an important mechanism to combat the infective agent. This activation of macrophages may contribute to the development of chronic inflammation instead of inflammation resolution.

Place, publisher, year, edition, pages
Oxford University Press, 2008
Keywords
Staphylococcus epidermidis infection; neutrophil; macrophage; chronic inflammation; phagocytosis; TNF-α; TNF-alpha
National Category
Immunology
Identifiers
urn:nbn:se:hj:diva-5576 (URN)10.1111/j.1574-695X.2008.00412.x (DOI)000255644300016 ()18400011 (PubMedID)2-s2.0-43349091469 (Scopus ID)
Available from: 2008-05-09 Created: 2008-05-09 Last updated: 2019-08-30Bibliographically approved
Nilsdotter-Augustinsson, Å., Wilsson, Å., Larsson, J., Stendahl, O., Öhman, L. & Lundqvist-Gustafsson, H. (2004). Staphylococcus aureus, but not Staphylococcus epidermidis, modulates the oxidative response and induces apoptosis in human neutrophils. Acta Pathologica, Microbiologica et Immunologica Scandinavica (APMIS), 112(2), 109-118
Open this publication in new window or tab >>Staphylococcus aureus, but not Staphylococcus epidermidis, modulates the oxidative response and induces apoptosis in human neutrophils
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2004 (English)In: Acta Pathologica, Microbiologica et Immunologica Scandinavica (APMIS), ISSN 0903-4641, E-ISSN 1600-0463, Vol. 112, no 2, p. 109-118Article in journal (Refereed) Published
Identifiers
urn:nbn:se:hj:diva-4388 (URN)
Available from: 2007-11-12 Created: 2007-11-12 Last updated: 2017-12-12Bibliographically approved
Lundqvist-Gustafsson, H., Norrman, S., Nilsson, J. & Wilsson, Å. (2001). Involvement of p38-mitogen-activated protein kinase in Staphylococcus aureus-induced neutrophil apoptosis.. Journal of Leukocyte Biology, 70(4), 642-648
Open this publication in new window or tab >>Involvement of p38-mitogen-activated protein kinase in Staphylococcus aureus-induced neutrophil apoptosis.
2001 (English)In: Journal of Leukocyte Biology, ISSN 0741-5400, E-ISSN 1938-3673, Vol. 70, no 4, p. 642-648Article in journal (Refereed) Published
Identifiers
urn:nbn:se:hj:diva-4389 (URN)
Available from: 2007-11-12 Created: 2007-11-12 Last updated: 2017-12-12Bibliographically approved
Wilsson, Å. (2000). On the interaction between huamn neutrophils andStaphylococcus aureus. (Doctoral dissertation).
Open this publication in new window or tab >>On the interaction between huamn neutrophils andStaphylococcus aureus
2000 (English)Doctoral thesis, monograph (Other scientific)
Identifiers
urn:nbn:se:hj:diva-4390 (URN)
Available from: 2007-11-12 Created: 2007-11-12
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