Change search
Link to record
Permanent link

Direct link
BETA
Strindhall, Jan
Alternative names
Publications (10 of 16) Show all publications
Pawelec, G., Akbar, A., Beverly, P., Caruso, C., Derhovanessian, E., Fülöp, T., . . . Wills, M. (2010). Immunosenescence and Cytomegalovirus:where do we stand after a decade?. Immunity & Ageing, 7(13)
Open this publication in new window or tab >>Immunosenescence and Cytomegalovirus:where do we stand after a decade?
Show others...
2010 (English)In: Immunity & Ageing, ISSN 1742-4933, E-ISSN 1742-4933, Vol. 7, no 13Article in journal (Refereed) Published
Identifiers
urn:nbn:se:hj:diva-15913 (URN)
Available from: 2011-08-25 Created: 2011-08-25 Last updated: 2017-12-08Bibliographically approved
Rodhe, N., Löfgren, S., Strindhall, J., Matussek, A. & Mölstad, S. (2009). Cytokines in urine in elderly subjects with acute cystitis and asymptomatic bacteriuria.. Scandinavian Journal of Primary Health Care, 27(2), 74-79
Open this publication in new window or tab >>Cytokines in urine in elderly subjects with acute cystitis and asymptomatic bacteriuria.
Show others...
2009 (English)In: Scandinavian Journal of Primary Health Care, ISSN 0281-3432, E-ISSN 1502-7724, Vol. 27, no 2, p. 74-79Article in journal (Refereed) Published
Abstract [en]

Objective. Searching for useful diagnostic tools to discriminate between asymptomatic bacteriuria (ASB) and acute cystitis, this study compared urinary levels of cytokines/chemokines and leukocyte esterase in three groups of elderly subjects; those with acute cystitis, those with ASB, and those without bacteriuria. Design. Comparative laboratory. Setting. Primary care. Subjects. A total of 16 patients with acute cystitis, 24 subjects with ASB, and 20 controls without bacteriuria, all of whom were aged 80 or over. Main outcome measures. Urinary levels of IL-1, TNF-, IL-12, IL-18, CXCL1 (GRO-), CXCL8 (IL-8), CCL2 (MCP-1), IL-6, IL-10, and leukocyte esterase. Results. Urinary levels of CXCL1, CXCL8, and IL-6 were significantly higher in acute cystitis patients than in the ASB group. The sensitivities and specificities for CXCL8, IL-6, and leukocyte esterase to discriminate between acute cystitis and ASB were 63% (95% CI 36-84) and 96% (95% CI 77-100) (cut-off 285 pg/mg creatinine), 81% (95% CI 54-95) and 96% (95% CI 77-100) (cut-off 30 pg/mg creatinine), and 88% (95% CI 60-98) and 79% (95% CI 57-92) (cut-off 2, on a scale of 0-4), respectively. Conclusions. The results indicate that measurement of urinary cytokines, and also leukocyte esterase, when using a cut-off value 2, could be useful in clinical practice to discriminate between symptomatic and asymptomatic urinary tract infections in the elderly. A combination of IL-6 and leukocyte esterase could be even more useful. This needs to be evaluated in prospective studies on the diagnosis and treatment of urinary tract infections in an elderly population.

Place, publisher, year, edition, pages
Taylor & Francis, 2009
Keywords
Aged; bacteriuria; chemokines; cytokines; CXCL8; family practice; interleukin-6; leukocyte esterase; urinary tract infections
National Category
Public Health, Global Health, Social Medicine and Epidemiology
Identifiers
urn:nbn:se:hj:diva-9292 (URN)10.1080/02813430902757634 (DOI)000266278900004 ()19247873 (PubMedID)2-s2.0-66149143559 (Scopus ID)
Available from: 2009-06-04 Created: 2009-06-04 Last updated: 2019-08-30Bibliographically approved
Pawelec, G., Derhovanessian, E., Larbi, A., Strindhall, J. & Wikby, A. (2009). Cytomegalovirus and human immunosenescence. Reviews in Medical Virology, 19(1), 47-56
Open this publication in new window or tab >>Cytomegalovirus and human immunosenescence
Show others...
2009 (English)In: Reviews in Medical Virology, ISSN 1052-9276, E-ISSN 1099-1654, Vol. 19, no 1, p. 47-56Article, review/survey (Refereed) Published
Abstract [en]

'Immunosenescence' is all imprecise term used to describe deleterious age-associated changes to immune parameters observed in all mammals studied so far. Primarily anecdotal evidence implies that failing immunity is responsible for the increased incidence and severity of infectious disease in old people. However, there is a serious dearth of accurate hard data concerning the actual cause of death in the elderly and the contribution thereto of the multitude of age-associated alterations measured in the immune system. Cross-sectional studies comparing those currently young With those currently old reveal a large number of differences in the distribution of immune cell types in the blood, and to some extent the functional integrity of those cells. Many of these parameters differ markedly between individuals infected with CMV and uninfected people, regardless of infection with other persistent herpesviruses. The adaptive arm of immunity appears to be more seriously affected than the innate arm, particularly the T lymphocytes. However, cross-sectional studies suffer the disadvantage that like is not being compared with like, because the conditions applied during the entire life course of the currently elderly were different from those applied now to the young. These differences in environment, nutrition, pathology and possibly genetics, rather than merely age, may be expected to influence the parameters studied. Moreover, pathogen exposure of the currently elderly was also different from contemporary exposure, probably including CMV. Some of the problems associated with cross-sectional studies can be overcome by performing longitudinal studies, as pointed out in an earlier analysis of the Baltimore Longitudinal Ageing study looking at lymphocyte numbers. However, longitudinal studies are challenging in humans. L Nonetheless, the pioneering Swedish OCTO/NONA studies of the very elderly which for the first time included a range of immune parameters, have identified a set of immune parameters predicting mortality at 2, 4 and 6 year follow-up; CMV infection makes a material contribution to this so-called immune risk profile (IRP)'. Whether the IRP is informative in younger individuals and the mechanism of the CMV effect is discussed in this review. 

Place, publisher, year, edition, pages
John Wiley & Sons, 2009
National Category
Immunology
Identifiers
urn:nbn:se:hj:diva-9294 (URN)10.1002/rmv.598 (DOI)000262519600004 ()19035529 (PubMedID)2-s2.0-60549096353 (Scopus ID)
Available from: 2009-06-04 Created: 2009-06-04 Last updated: 2019-08-30Bibliographically approved
Stark, L., Matussek, A., Strindhall, J., Geffers, R., Buer, J., Kihlström, E., . . . Lindgren, P. (2009). Staphylococcus aureus isolates from blood and anterior nares induce similar innate immune responses in endothelial cells. APMIS: Acta pathologica, microbiologica et immunologica Scandinavica. Supplementum, 117(11), 814-824
Open this publication in new window or tab >>Staphylococcus aureus isolates from blood and anterior nares induce similar innate immune responses in endothelial cells
Show others...
2009 (English)In: APMIS: Acta pathologica, microbiologica et immunologica Scandinavica. Supplementum, ISSN 0903-465X, E-ISSN 1600-5503, Vol. 117, no 11, p. 814-824Article in journal (Refereed) Published
Abstract [en]

To evaluate the possibility to distinguish virulent from non-virulent isolates, gene expression in human umbilical vein endothelial cells (HUVEC) induced by invasive and colonizing isolates of Staphylococcus aureus was compared. Gene expression in HUVEC was analyzed by microarray analysis after 4 h of infection with Staphylococcus aureus, isolated from healthy nasal carriers (n = 5) and from blood of septic patients (n = 5), to explore possible differences between the groups of bacteria in interaction with HUVEC. All isolates were spa-typed to disclose strain relatedness. Moreover, the isolates were characterized with DNA microarray to determine the presence of virulence genes and to investigate the potential genes of importance in HUVEC interaction. The expression of 41 genes was up-regulated, and four were down-regulated in HUVEC by all isolates. Most of the up-regulated genes encode cytokines, chemokines, interferon-induced proteins, proteins regulating apoptosis and cell proliferation. There was no difference in the gene expression pattern between HUVEC infected with invasive or colonizing isolates. Furthermore, there was no difference in the presence of bacterial virulence genes between the two groups. In conclusion, our data indicate that S. aureus isolates induce comparable expression patterns in HUVEC, irrespective of invasiveness or presence of virulence genes. 

Place, publisher, year, edition, pages
John Wiley & Sons, 2009
Keywords
Staphylococcus aureus; HUVEC; infection; gene expression; virulence
National Category
Immunology
Identifiers
urn:nbn:se:hj:diva-11285 (URN)10.1111/j.1600-0463.2009.02535.x (DOI)000270958100006 ()19845532 (PubMedID)2-s2.0-70350345344 (Scopus ID)
Available from: 2010-01-12 Created: 2010-01-12 Last updated: 2019-09-02Bibliographically approved
Wikby, A., Månsson, I. A., Johansson, B., Strindhall, J. & Nilsson, S. E. (2008). The immune risk profile is associated with age and gender: findings from three Swedish population studies of individuals 20-100 years of age.. Biogerontology (Dordrecht), 9(5), 299-308
Open this publication in new window or tab >>The immune risk profile is associated with age and gender: findings from three Swedish population studies of individuals 20-100 years of age.
Show others...
2008 (English)In: Biogerontology (Dordrecht), ISSN 1389-5729, E-ISSN 1573-6768, Vol. 9, no 5, p. 299-308Article in journal (Refereed) Published
Abstract [en]

Earlier we identified an Immune Risk Profile (IRP) of very old individuals, 86-94 years of age, characterised by an inverted CD4/CD8 ratio and associated with persistent cytomegalovirus infection and an increase in the numbers of CD3+CD8+CD28- cells. In the present study we included data from a population-based sample in the age range of 20-79 years to examine the prevalence of individuals with an inverted CD4/CD8 ratio relative to age and gender across the entire adult lifespan. Immunological monitoring that was conducted included analysis of the numbers of T-cells in the subsets CD3+, CD3+CD4+, and CD3+CD8+ as well as CD3+CD8+CD28+, CD3+CD8+CD28-, and CD8+CD45RA+CCR7+. There was found to be a significant lowering of the numbers of CD3+, CD3+CD4+, and CD3+CD8+, and of the CD8+CD45RA+CCR7+ cells across the adult life-span. Notably, the prevalence of individuals with an inverted CD4/CD8 ratio increased from about 8% in the age range of 20-59 years to about 16% in the age range of 60-94 years. The mortality rate in individuals with an inverted CD4/CD8 ratio also increased significantly above the age of 60. Interestingly, the proportion of individuals with an inverted CD4/CD8 ratio was found to be significantly higher in men, whereas the numbers of CD3+CD4+ helper and CD8+CD45RA+CCR7+ naive cells and the CD4/CD8 ratio were found to be significantly higher in women. These results highlight the importance of functioning of the thymus in the development of IRP and may partly account for the differences between sexes in terms of longevity.

Place, publisher, year, edition, pages
Springer, 2008
Keywords
immune risk; T-cells; age; gender
National Category
Gerontology, specialising in Medical and Health Sciences
Identifiers
urn:nbn:se:hj:diva-7041 (URN)10.1007/s10522-008-9138-6 (DOI)000258653600002 ()18369735 (PubMedID)2-s2.0-50649111879 (Scopus ID)
Available from: 2008-12-10 Created: 2008-12-10 Last updated: 2019-09-02Bibliographically approved
Koch, S., Larbi, A., Ozcelik, D., Solana, R., Gouttefangeas, C., Attig, S., . . . Pawelec, G. (2007). Cytomegalovirus infection: a driving force in human T cell immunosenescence.. Annals of the New York Academy of Sciences (1114), 23-35
Open this publication in new window or tab >>Cytomegalovirus infection: a driving force in human T cell immunosenescence.
Show others...
2007 (English)In: Annals of the New York Academy of Sciences, ISSN 0077-8923, E-ISSN 1749-6632, no 1114, p. 23-35Article in journal (Refereed) Published
Identifiers
urn:nbn:se:hj:diva-4387 (URN)17986574 (PubMedID)
Available from: 2007-11-09 Created: 2007-11-09 Last updated: 2017-12-12Bibliographically approved
Strindhall, J., Nilsson, B.-O., Löfgren, S., Ernerudh, J., Pawelec, G., Johansson, B. & Wikby, A. (2007). No Immune Risk Profile among individuals who reach 100 years of age: findings from the Swedish NONA immune longitudinal study.. Experimental Gerontology, 42(8), 753-761
Open this publication in new window or tab >>No Immune Risk Profile among individuals who reach 100 years of age: findings from the Swedish NONA immune longitudinal study.
Show others...
2007 (English)In: Experimental Gerontology, ISSN 0531-5565, E-ISSN 1873-6815, Vol. 42, no 8, p. 753-761Article in journal (Refereed) Published
National Category
Other Social Sciences not elsewhere specified
Identifiers
urn:nbn:se:hj:diva-4287 (URN)17606347 (PubMedID)
Available from: 2007-11-15 Created: 2007-11-15 Last updated: 2017-12-12Bibliographically approved
Hadrup, S. R., Strindhall, J., Køllgaard, T., Seremet, T., Johansson, B., Pawelec, G., . . . Wikby, A. (2006). Longitudinal studies of clonally expanded CD8 T cells reveal a repertoire shrinkage predicting mortality and an increased number of dysfunctional cytomegalovirus-specific T cells in the very elderly.. Journal of Immunology, 176(4), 2645-2653
Open this publication in new window or tab >>Longitudinal studies of clonally expanded CD8 T cells reveal a repertoire shrinkage predicting mortality and an increased number of dysfunctional cytomegalovirus-specific T cells in the very elderly.
Show others...
2006 (English)In: Journal of Immunology, ISSN 0022-1767, E-ISSN 1550-6606, Vol. 176, no 4, p. 2645-2653Article in journal (Refereed) Published
Keywords
Aged; 80 and over, Aging/*immunology, CD4-Positive T-Lymphocytes/immunology, CD8-Positive T-Lymphocytes/cytology/*immunology/*pathology, Clone Cells/cytology/immunology, Cytomegalovirus/*immunology, Cytomegalovirus Infections/*immunology/*mortality/virology, Female, Humans, Interferon Type II/secretion, Longitudinal Studies, Male, Phenotype, Receptors; Antigen; T-Cell/immunology
National Category
Other Social Sciences not elsewhere specified
Identifiers
urn:nbn:se:hj:diva-4282 (URN)16456027 (PubMedID)
Available from: 2007-10-31 Created: 2007-10-31 Last updated: 2017-12-12Bibliographically approved
Wikby, A., Nilsson, B.-O., Forsey, R., Thompson, J., Strindhall, J., Löfgren, S., . . . Johansson, B. (2006). The immune risk phenotype is associated with IL-6 in the terminal decline stage: findings from the Swedish NONA immune longitudinal study of very late life functioning.. Mechanisms of Ageing and Development, 127(8), 695-704
Open this publication in new window or tab >>The immune risk phenotype is associated with IL-6 in the terminal decline stage: findings from the Swedish NONA immune longitudinal study of very late life functioning.
Show others...
2006 (English)In: Mechanisms of Ageing and Development, ISSN 0047-6374, E-ISSN 1872-6216, Vol. 127, no 8, p. 695-704Article in journal (Refereed) Published
Keywords
Aged; 80 and over, Aging/*immunology, Albumins/immunology, Body Weight, C-Reactive Protein/analysis, CD4-CD8 Ratio, Female, Humans, Infection, Inflammation, Interleukin-6/*blood, Longitudinal Studies, Male, Prealbumin/analysis, T-Lymphocytes/cytology/*immunology
National Category
Other Social Sciences not elsewhere specified
Identifiers
urn:nbn:se:hj:diva-4295 (URN)16750842 (PubMedID)
Available from: 2007-10-31 Created: 2007-10-31 Last updated: 2017-12-12Bibliographically approved
Wikby, A., Ferguson, F., Forsey, R., Thompson, J., Strindhall, J., Löfgren, S., . . . Johansson, B. (2005). An immune risk phenotype, cognitive impairment, and survival in very late life: impact of allostatic load in Swedish octogenarian and nonagenarian humans.. The journals of gerontology. Series A, Biological sciences and medical sciences, 60(5), 556-565
Open this publication in new window or tab >>An immune risk phenotype, cognitive impairment, and survival in very late life: impact of allostatic load in Swedish octogenarian and nonagenarian humans.
Show others...
2005 (English)In: The journals of gerontology. Series A, Biological sciences and medical sciences, ISSN 1079-5006, E-ISSN 1758-535X, Vol. 60, no 5, p. 556-565Article in journal (Refereed) Published
Keywords
Aged, Aged; 80 and over, Aging/*immunology, Analysis of Variance, Antigens; CD/*immunology, CD4-CD8 Ratio, Cognition Disorders/*immunology/*mortality, Cohort Studies, Female, Geriatric Assessment, Health Status Indicators, Humans, Immunocompromised Host, Interleukin-2/genetics/immunology, Interleukin-6/genetics/immunology, Life Expectancy, Longevity, Longitudinal Studies, Male, Phenotype, Probability, Risk Assessment, Statistics; Nonparametric, Survival Rate, Sweden
National Category
Other Social Sciences not elsewhere specified
Identifiers
urn:nbn:se:hj:diva-4283 (URN)15972602 (PubMedID)
Available from: 2007-11-15 Created: 2007-11-15 Last updated: 2017-12-12Bibliographically approved
Organisations

Search in DiVA

Show all publications