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Åström Malm, I., De Basso, R. & Blomstrand, P. (2023). No differences in FBN1 genotype between men with and without abdominal aortic aneurysm. BMC Cardiovascular Disorders, 23(1), Article ID 36.
Open this publication in new window or tab >>No differences in FBN1 genotype between men with and without abdominal aortic aneurysm
2023 (English)In: BMC Cardiovascular Disorders, ISSN 1471-2261, E-ISSN 1471-2261, Vol. 23, no 1, article id 36Article in journal (Refereed) Published
Abstract [en]

Background: Abdominal aortic aneurysm (AAA) is an aortic enlargement in which the transverse diameter reaches at least 30 mm. Certain risk factors, such as age, male gender, and smoking, are well known; however, less is known about the genetic factors involved. Fibrillin-1 (FBN1) is a protein that coordinates the deposition of elastin fibres in the extracellular matrix and is therefore likely to affect the elastic properties in the aortic wall. Previously studies have found associations between the FBN1-2/3 genotype and arterial stiffness, but how different FBN1 genotypes, AAA, and arterial stiffness are related has been less frequently investigated. Aim: This study aimed to investigate whether there is a difference in FBN1 genotype between men with and without AAA. A further aim was to study whether the FBN1 genotype affects arterial wall stiffness differently in men with and without AAA. Methods: Pulse wave velocity and FBN1 genotyping were performed in 229 men (159 with AAA, 70 without AAA). Participants were recruited from ultrasound AAA surveillance programs or ongoing ultrasound screening programs from 2011 to 2016. Results: The distribution of the FBN1 genotype in the AAA and control groups were as follows: FBN1-2/2: 62% vs. 64%; FBN1-2/3: 8% vs. 14%; and FBN1-2/4: 30% vs. 21%, respectively. Men with AAA and FBN1-2/2 had increased central pulse wave velocity (p < 0.005) compared to the control group (those without AAA) with the FBN1-2/2 genotype. Conclusion: No differences were found with respect to FBN1 genotypes between men with and without AAA. The development of AAA in men does not appear to be linked to a specific FBN1 genotype. Nevertheless, men with FBN1-2/2 and AAA have increased central arterial stiffness compared to men with the same FBN1 genotype but without AAA.

Place, publisher, year, edition, pages
BioMed Central (BMC), 2023
Keywords
Aorta, Aortic Aneurysm, Abdominal, Fibrillin-1, Genotype, Humans, Male, Pulse Wave Analysis, Risk Factors, FBN1 protein, human, fibrillin 1, abdominal aortic aneurysm, diagnostic imaging, genetics, human, pulse wave, risk factor, Arterial stiffness, FBN1
National Category
Cardiac and Cardiovascular Systems
Identifiers
urn:nbn:se:hj:diva-59719 (URN)10.1186/s12872-023-03068-3 (DOI)000916025200001 ()36670346 (PubMedID)2-s2.0-85146610191 (Scopus ID)GOA;;860441 (Local ID)GOA;;860441 (Archive number)GOA;;860441 (OAI)
Funder
Futurum - Academy for Health and Care, Jönköping County Council, SwedenKonung Gustaf V:s och Drottning Victorias FrimurarestiftelseMedical Research Council of Southeast Sweden (FORSS), 34931Swedish Heart Lung Foundation, 20130650Swedish Research Council, 12661
Available from: 2023-02-06 Created: 2023-02-06 Last updated: 2023-02-16Bibliographically approved
Åström Malm, I., De Basso, R., Blomstrand, P. & Wågsäter, D. (2022). Association of IL-10 and CRP with Pulse Wave Velocity in Patients with Abdominal Aortic Aneurysm. Journal of Clinical Medicine, 11(5), Article ID 1182.
Open this publication in new window or tab >>Association of IL-10 and CRP with Pulse Wave Velocity in Patients with Abdominal Aortic Aneurysm
2022 (English)In: Journal of Clinical Medicine, E-ISSN 2077-0383, Vol. 11, no 5, article id 1182Article in journal (Refereed) Published
Abstract [en]

Background: Markers of inflammation and arterial stiffness are predictors of cardiovascular morbidity and events, but their roles in the mechanisms and progression of abdominal aortic aneurysm (AAA) in males have not been fully investigated. This study explored possible associations between inflammatory marker levels and arterial stiffness in males with AAA. Methods: A total of 270 males (191 AAA and 79 controls) were included in the study. Arterial stiffness was assessed using non-invasive applanation tonometry to measure the regional pulse wave velocity between the carotid and femoral arteries and the carotid and radial arteries. Blood samples were obtained, and interleukin-10 (IL-10) and CRP levels were analysed. Results: Subjects with an AAA had higher levels of IL-10 (21.5 ± 14.0 ng/mL versus 16.6 ± 9.3 ng/mL) compared to controls (p = 0.007). In the AAA cohort, subjects with T2DM showed higher levels of IL-10 (26.4 ± 17.3 versus 20.4 ± 13.0, p = 0.036). We observed a positive correlation between PWVcf and CRP in the control group (r = 0.332) but not the AAA group. PWVcf and CRP were negatively correlated (r = 0.571) in the T2DM subjects treated with metformin in the AAA group. Conclusion: Arterial stiffness is related to the degree of inflammation reflected by CRP and IL-10 levels in males with an AAA. IL-10 is negatively correlated with arterial stiffness in these subjects. This finding suggests that IL-10 may decrease arterial stiffness in males with AAA. The negative correlation between CRP and PWVcf in males with T2DM treated with metformin may indicate that metformin influences the arterial wall to decrease stiffness in subjects with AAA.

Place, publisher, year, edition, pages
MDPI, 2022
Keywords
Abdominal aortic aneurysm, Arterial stiffness, Diabetes mellitus type 2, Inflammatory marker
National Category
Cardiac and Cardiovascular Systems
Identifiers
urn:nbn:se:hj:diva-56003 (URN)10.3390/jcm11051182 (DOI)000771434300001 ()35268272 (PubMedID)2-s2.0-85125068777 (Scopus ID)GOA;;798884 (Local ID)GOA;;798884 (Archive number)GOA;;798884 (OAI)
Funder
Futurum - Academy for Health and Care, Jönköping County Council, SwedenKonung Gustaf V:s och Drottning Victorias FrimurarestiftelseSwedish Heart Lung Foundation, 20130650Medical Research Council of Southeast Sweden (FORSS), 34931Swedish Research Council, 12661
Available from: 2022-03-07 Created: 2022-03-07 Last updated: 2022-05-17Bibliographically approved
Åström Malm, I., De Basso, R., Engvall, J. & Blomstrand, P. (2022). Males with abdominal aortic aneurysm have reduced left ventricular systolic and diastolic function. Clinical Physiology and Functional Imaging, 42(1), 1-7
Open this publication in new window or tab >>Males with abdominal aortic aneurysm have reduced left ventricular systolic and diastolic function
2022 (English)In: Clinical Physiology and Functional Imaging, ISSN 1475-0961, E-ISSN 1475-097X, Vol. 42, no 1, p. 1-7Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Abdominal aortic aneurysm (AAA) increases the risk of chronic heart failure and other major cardiovascular events. Knowledge about left ventricular function in patients with AAA is lacking. This echocardiographic study aimed to investigate whether AAA is associated with left ventricular systolic and diastolic dysfunction.

METHODS: Echocardiography was performed in 307 males (199 AAA and 108 controls) recruited from a regional ultrasound surveillance programme of known AAA, or from an ongoing ultrasound screening programme, during 2011-2016.

RESULTS: Subjects with AAA had thicker septal and posterior walls and a reduced left ventricular function compared to controls. Left ventricular ejection fraction (AAA 55 ± 8%, controls 57 ± 7%) and global longitudinal strain (AAA 19 ± 3%, controls 20 ± 3%) were lower in the group with AAA (both p < 0·05). Moreover, decreased mitral annular plane systolic excursion (12 ± 2 mm versus 13 ± 2 mm) and higher E/e' (13 ± 5 versus 11 ± 4) were observed in subjects with AAA (both p < 0·05). The aortic sinus (38 ± 4 mm versus 35 ± 2 mm) and ascending aorta (36 ± 4 mm versus 34 ± 5 mm) were also wider in the AAA group compared to controls (both p < 0·01).

CONCLUSION: AAAs are associated with reduced left ventricular systolic and diastolic function in males. The larger diameter of the aortic sinus and ascending aorta among AAA patients suggests that AAA is a general aortic disease.

Place, publisher, year, edition, pages
John Wiley & Sons, 2022
Keywords
AAA, arteries, cardiovascular risk assessment, echocardiography, left ventricular dysfunction
National Category
Cardiac and Cardiovascular Systems
Identifiers
urn:nbn:se:hj:diva-54740 (URN)10.1111/cpf.12728 (DOI)000698854600001 ()34541748 (PubMedID)2-s2.0-85115637752 (Scopus ID)HOA;;767447 (Local ID)HOA;;767447 (Archive number)HOA;;767447 (OAI)
Funder
Swedish Heart Lung FoundationRegion ÖstergötlandMedical Research Council of Southeast Sweden (FORSS)
Available from: 2021-09-27 Created: 2021-09-27 Last updated: 2022-05-17Bibliographically approved
Åström Malm, I., De Basso, R., Blomstrand, P. & Bjarnegård, N. (2021). Increased arterial stiffness in males with abdominal aortic aneurysm. Clinical Physiology and Functional Imaging, 41(1), 68-75
Open this publication in new window or tab >>Increased arterial stiffness in males with abdominal aortic aneurysm
2021 (English)In: Clinical Physiology and Functional Imaging, ISSN 1475-0961, E-ISSN 1475-097X, Vol. 41, no 1, p. 68-75Article in journal (Refereed) Published
Abstract [en]

Background: Abdominal aortic aneurysm (AAA), a localized dilatation of the abdominal aorta, has a prevalence of about 1.5%–3% among 65- to 70-year-old males in Europe. AAA confers an increased risk of developing major cardiovascular events in addition to the risk of aneurysm rupture. The aim of this study was to evaluate whether the arterial wall distensibility is altered in subjects with AAA.

Methods: Two hundred and eighty-four male subjects (182 with AAA and 102 controls) were enrolled in the study. Arterial wall distensibility was evaluated using non-invasive applanation tonometry to measure regional pulse wave velocity between the carotid and femoral arteries and the carotid and radial arteries. In addition, blood pressure was measured, and the pulse pressure waveform was analysed.

Results: Higher aortic augmentation index (25.1% versus 20.6%; p <.001) and higher aortic pulse wave velocity (12.3 m/s versus 10.9 m/s; p <.001) were demonstrated in the AAA cohort. The slightly higher arm pulse wave velocity in the AAA group (9.4 m/s versus 9.1 m/s; p <.05) was abolished after adjusting for mean arterial blood pressure.

Conclusions: Males with AAA have decreased aortic wall distensibility and enhanced reflection waves in central aorta during systole. These results imply that increased arterial wall stiffness may be a contributing factor to the overall higher cardiovascular risk seen in patients with AAA.

Place, publisher, year, edition, pages
John Wiley & Sons, 2021
Keywords
arteries, blood pressure, cardiovascular risk assessment, distensibility, pulse wave velocity
National Category
Pharmacology and Toxicology
Identifiers
urn:nbn:se:hj:diva-50891 (URN)10.1111/cpf.12667 (DOI)000579156800001 ()33000520 (PubMedID)2-s2.0-85092613380 (Scopus ID)HOA (Local ID)HOA (Archive number)HOA (OAI)
Funder
Medical Research Council of Southeast Sweden (FORSS)Swedish Heart Lung Foundation
Available from: 2020-10-28 Created: 2020-10-28 Last updated: 2022-05-17Bibliographically approved
Åström Malm, I., De Basso, R., Engvall, J. & Blomstrand, P. (2021). Males with abdominal aortic aneurysm have reduced left ventricle function. In: : . Paper presented at Artery 21, 21-23 October 2021, Paris, France.
Open this publication in new window or tab >>Males with abdominal aortic aneurysm have reduced left ventricle function
2021 (English)Conference paper, Poster (with or without abstract) (Refereed)
National Category
Cardiac and Cardiovascular Systems
Identifiers
urn:nbn:se:hj:diva-58430 (URN)
Conference
Artery 21, 21-23 October 2021, Paris, France
Available from: 2022-09-06 Created: 2022-09-06 Last updated: 2022-09-06Bibliographically approved
Unosson, J., Wågsäter, D., Bjarnegård, N., De Basso, R., Welander, M., Mani, K., . . . Wanhainen, A. (2021). Metformin Prescription Associated with Reduced Abdominal Aortic Aneurysm Growth Rate and Reduced Chemokine Expression in a Swedish Cohort. Annals of Vascular Surgery, 70, 425-433
Open this publication in new window or tab >>Metformin Prescription Associated with Reduced Abdominal Aortic Aneurysm Growth Rate and Reduced Chemokine Expression in a Swedish Cohort
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2021 (English)In: Annals of Vascular Surgery, ISSN 0890-5096, E-ISSN 1615-5947, Vol. 70, p. 425-433Article in journal (Refereed) Published
Abstract [en]

Background: Recent reports suggest that the negative association between diabetes mellitus and abdominal aortic aneurysm (AAA) may be driven by metformin, the world's most common antidiabetic drug rather than diabetes per se. We sought to investigate the association among AAA growth rate, chemokine profile, and metformin prescription in a contemporary Swedish cohort.

Methods: Patients under surveillance for small AAA were identified at 4 Swedish vascular centers with active AAA screening programs. Annual AAA growth rate, medical history, and prescribed medications were recorded for linear regression analysis. In a subset of patients with AAA and control subjects without AAA or diabetes, plasma samples were available and analyzed for 40 inflammatory chemokines.

Results: A total of 526 patients were included for AAA growth analysis: 428 without type 2 diabetes mellitus (T2DM), 65 with T2DM and metformin prescription, and 33 with T2DM but without metformin prescription. Patients were included from 2005 to 2017 with mean follow-up of 3.2 (1.7) years and median annual AAA growth rate 1.6 mm, range −4.8 to 15.4 mm. Mean (standard deviation) annual AAA growth rates were 2.3 (2.2) mm in non-T2DM patients versus 1.1 (1.1) mm in patients with T2DM with metformin prescription and 1.6 (1.4) mm among those with T2DM without metformin prescription. With non-T2DM patients as reference in an unadjusted and 2 adjusted models, metformin prescription was significantly associated with reduced AAA growth rate (P < 0.001, P = 0.005, and P = 0.024, respectively), but not T2DM without metformin prescription (P = 0.137, P = 0.331, and P = 0.479, respectively). Among 240 patients with AAA (152 without T2DM, 51 with T2DM and metformin, and 37 with T2DM without metformin) and 59 without AAA or T2DM, metformin prescription was associated with reduced expression of chemokines representing all classes of leukocytes.

Conclusions: Metformin prescription is associated with reduced AAA growth rate, possibly mediated by broad anti-inflammatory effects. A randomized controlled trial is needed to determine what role metformin may play in AAA disease, particularly in the absence of T2DM. 

Place, publisher, year, edition, pages
Elsevier, 2021
National Category
Biomedical Laboratory Science/Technology
Identifiers
urn:nbn:se:hj:diva-50329 (URN)10.1016/j.avsg.2020.06.039 (DOI)000599833300059 ()32619497 (PubMedID)2-s2.0-85088959431 (Scopus ID)HOA (Local ID)HOA (Archive number)HOA (OAI)
Funder
Swedish Research Council, K2013-64X-20406-07-3, 2019-01673Swedish Heart Lung Foundation, 1015-0596, 20190556, 2012-0353
Available from: 2020-08-20 Created: 2020-08-20 Last updated: 2021-02-19Bibliographically approved
Åström Malm, I., Alehagen, U., Blomstrand, P., Dahlström, U. & De Basso, R. (2020). Higher blood pressure in elderly hypertensive females, with increased arterial stiffness and blood pressure in females with the Fibrillin-1 2/3 genotype. BMC Cardiovascular Disorders, 20(1), Article ID 180.
Open this publication in new window or tab >>Higher blood pressure in elderly hypertensive females, with increased arterial stiffness and blood pressure in females with the Fibrillin-1 2/3 genotype
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2020 (English)In: BMC Cardiovascular Disorders, ISSN 1471-2261, E-ISSN 1471-2261, Vol. 20, no 1, article id 180Article in journal (Refereed) Published
Abstract [en]

Background: Elderly patients have a relatively high cardiovascular risk due to increased arterial stiffness, elevated blood pressure and decreased amounts of elastin in the arteries. The composition of the media layer in the arterial wall, comprising elastin, collagen, smooth muscle cells, proteoglycans, fibronectin and fibrillin-1, influences its mechanical properties. Mutations in the fibrillin-1 gene leads to increased aortic stiffness, elevated pulse pressure and aortic root dilatation. This study investigates whether there is a sex difference among hypertensive elderly patients regarding blood pressure, arterial stiffness and fibrillin-1 genotypes. Methods: A total of 315 hypertensive subjects (systolic blood pressure > 140 mmHg) were included in this study (155 men and 160 women aged 71-88 years). Aortic pulse wave velocity and augmentation index were determined using SphygmoCor, and brachial blood pressure was measured using an oscillometric technique. Fibrillin-1 was genotyped by polymerase chain reaction and with a capillary electrophoresis system. Results: Females showed a significantly higher peripheral mean arterial pressure (females; 107.20 mmHg, males 101.6 mmHg, p = 0.008), central mean arterial pressure (females; 107.2 mmHg, males 101.6 mmHg p = 0.008), central systolic blood pressure (females; 148.1 mmHg, males 139.2 mmHg, p < 0.001) and central pulse pressure (females; 68.9 mmHg, males 61.6 mmHg, p = 0.035) than males. Females with the Fibrillin-1 2/3 genotype showed a significantly higher augmentation index (FBN1 2/3; 39.9%, FBN1 2/2 35.0%, FBN1 2/4 35.8, p = 0.029) and systolic blood pressure (FBN1 2/3; 174.6 mmHg, FBN1 2/2168.9 mmHg, FBN1 2/4169.9 mmHg, p = 0.025) than females with the 2/2 and 2/4 genotypes. Conclusion: The findings of this study may indicate that hypertensive elderly females, especially elderly females with Fibrillin-1 2/3, have increased systolic blood pressure and arterial stiffness. 

Place, publisher, year, edition, pages
BioMed Central, 2020
Keywords
Arterial stiffness, Elderly, Female, Fibrillin-1, Hypertension, fibrillin, fibrillin 1, fibrillin 2, fibrillin 3, unclassified drug, aged, Article, augmentation index, blood pressure measurement, blood sampling, capillary electrophoresis, controlled study, cross-sectional study, elevated blood pressure, genotype, human, major clinical study, male, mean arterial pressure, oscillometry, polymerase chain reaction, population research, priority journal, pulse pressure, pulse wave, sex difference, systolic blood pressure
National Category
Gerontology, specialising in Medical and Health Sciences
Identifiers
urn:nbn:se:hj:diva-48586 (URN)10.1186/s12872-020-01454-9 (DOI)000528913700002 ()32303188 (PubMedID)2-s2.0-85083299006 (Scopus ID)GOA HHJ 2020 (Local ID)GOA HHJ 2020 (Archive number)GOA HHJ 2020 (OAI)
Funder
Swedish Research Council, 12661Medical Research Council of Southeast Sweden (FORSS), 34931Swedish Heart Lung Foundation, 20130650Futurum - Academy for Health and Care, Jönköping County Council, Sweden, 259701
Available from: 2020-05-29 Created: 2020-05-29 Last updated: 2022-05-17Bibliographically approved
Wanhainen, A., Mani, K., Vorkapic, E., De Basso, R., Björck, M., Länne, T. & Wågsäter, D. (2017). Screening of circulating microRNA biomarkers for prevalence of abdominal aortic aneurysm and aneurysm growth. Atherosclerosis, 256, 82-88
Open this publication in new window or tab >>Screening of circulating microRNA biomarkers for prevalence of abdominal aortic aneurysm and aneurysm growth
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2017 (English)In: Atherosclerosis, ISSN 0021-9150, E-ISSN 1879-1484, Vol. 256, p. 82-88Article in journal (Refereed) Published
Abstract [en]

Background and aims

MicroRNA (miR) are important regulators of gene expression and biological processes and have recently been suggested as possible biomarkers for abdominal aortic aneurysm (AAA) disease. The aim of the present study was to assess the role of miR as biomarkers for initiation and progression of AAA disease, through evaluation of a wide range of miRs in a large population-based cohort, with AAA patients with linked clinical data regarding risk factors, AAA size and growth, as well as controls.

Methods

The expression of the 172 most commonly expressed miRs in plasma was analyzed by real-time PCR in samples from 169 screening-detected AAA patients and 48 age-matched controls.

Results

For 103 miRs, there was a significant difference in expression between AAA and controls. Of these, 20 miRs were differently expressed between fast and slow growing aneurysms. These miRs target genes known to be involved in AAA disease as well as novel genes and pathways. By combining the top altered miRs together with clinical variables, strong predictive values, determining growth of AAA, were obtained (area under curve = 0.86, p < 0.001).

Conclusions

This large cohort study identified several novel miRs with altered expression in AAA patients when compared to controls. Assessment of miR expression may offer an opportunity to predict disease progression and aneurysm growth.

Place, publisher, year, edition, pages
Elsevier, 2017
Keywords
Biomarker, Plasma, Risk factor, Aneurysm, MicroRNA
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:hj:diva-34761 (URN)10.1016/j.atherosclerosis.2016.11.007 (DOI)000393891900012 ()27993388 (PubMedID)2-s2.0-85008191091 (Scopus ID)
Available from: 2017-01-17 Created: 2017-01-17 Last updated: 2017-11-29Bibliographically approved
De Basso, R., Sandgren, T., Ahlgren, Å. R. & Länne, T. (2015). Increased cardiovascular risk without generalized arterial dilating diathesis in persons who do not have abdominal aortic aneurysm but who are first-degree relatives of abdominal aortic aneurysm patients. Clinical and experimental pharmacology & physiology, 42(6), 576-581
Open this publication in new window or tab >>Increased cardiovascular risk without generalized arterial dilating diathesis in persons who do not have abdominal aortic aneurysm but who are first-degree relatives of abdominal aortic aneurysm patients
2015 (English)In: Clinical and experimental pharmacology & physiology, ISSN 0305-1870, E-ISSN 1440-1681, Vol. 42, no 6, p. 576-581Article in journal (Refereed) Published
Abstract [en]

There is a strong genetic predisposition towards abdominal aortic aneurysm (AAA), but it is unknown whether persons without AAA but with first-degree relatives who are AAA patients have a generalized dilating diathesis, defect arterial wall mechanics, or increased cardiovascular risk. The aim of the study was to investigate arterial diameters and wall mechanics at multiple arterial sites in these subjects and compare them with controls without a family history of AAA. This study included 118 first-degree relatives of patients with AAA and 66 controls (age: 40-80years). The abdominal aorta, common carotid artery, common femoral artery, and popliteal artery were investigated by echo-tracking ultrasound. The relatives had no arterial dilatation, but they did tend to have smaller diameters than controls. Relatives had a higher heart rate, diastolic blood pressure, and mean arterial pressure than controls. The distensibility coefficient and the compliance coefficient were decreased in all arteries in male relatives, adjusted for age and smoking; these coefficients were normalized after adjustment for mean arterial pressure and heart rate. Female relatives had a lower compliance coefficient in the abdominal aorta, adjusted for age and smoking. After adjustment for mean arterial pressure and heart rate, the difference disappeared. No general arterial dilatation in relatives without AAA was found, supporting the hypothesis that the dilating diathesis is linked to the aneurysmal manifestation in the abdominal aorta. Although the threat of aneurysmal dilatation and rupture seems to be lacking in these subjects, heart rate, blood pressure, and arterial wall stiffness were all increased, which may indicate a higher risk of developing cardiovascular morbidity and mortality.

Keywords
aneurysmal dilatation, arterial diameter, arterial stiffness, blood pressure
National Category
Pharmacology and Toxicology Physiology
Identifiers
urn:nbn:se:hj:diva-28376 (URN)10.1111/1440-1681.12395 (DOI)000355878500003 ()25882720 (PubMedID)
Available from: 2015-11-25 Created: 2015-11-25 Last updated: 2018-01-10Bibliographically approved
De Basso, R., Hedblad, B., Carlson, J., Persson, M., Östling, G. & Länne, T. (2014). Increased carotid plaque burden in men with the fibrillin-1 2/3 genotype. Clinical and experimental pharmacology & physiology, 41(9), 637-642
Open this publication in new window or tab >>Increased carotid plaque burden in men with the fibrillin-1 2/3 genotype
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2014 (English)In: Clinical and experimental pharmacology & physiology, ISSN 0305-1870, E-ISSN 1440-1681, Vol. 41, no 9, p. 637-642Article in journal (Refereed) Published
Abstract [en]

Fibrillin-1 (FBN1) is an important constituent of the vascular wall and earlier studies have indicated an effect of the FBN1 2/3 genotype on blood pressure as well as aortic stiffness in men. The aim of the present study was to determine whether the FBN1 2/3 genotype was associated with the presence of carotid plaque and incident cardiovascular morbidity and mortality in middle-aged subjects. The FBN1 genotype was characterized in 5765 subjects (2424 men, 3341 women; age 45-69years) recruited from the Malmo Diet and Cancer Study Cardiovascular Cohort, Sweden. Plaque occurrence and intima-media thickness (IMT) of the carotid artery were assessed by ultrasound. The incidence of first cardiovascular events (myocardial infarction and stroke) and cause-specific mortality were monitored over a mean follow-up period of 13.2years. The most common FBN1 genotypes were 2/2, 2/3 and 2/4, which accounted for 92.2% (n=5317) of subjects. There were no differences between the three genotypes regarding age, blood pressure, glucose, lipids, smoking habits, common carotid artery diameter and intima-media thickness in men and women. The presence of plaque in the carotid artery was higher in men with the 2/3 genotype compared with the 2/2 and 2/4 genotypes (55% vs 46% and 50%, respectively; P=0.007). No similar differences were observed in women. No significant relationship was observed between FBN1 genotypes and the incidence of cardiovascular disease or all-cause mortality. The increased prevalence of plaque in the carotid artery of middle-aged men with the FBN1 2/3 genotype indicates pathological arterial wall remodelling with a more pronounced atherosclerotic burden.

Keywords
arterial wall, blood pressure, cardiovascular risk, human, intima-media thickness
National Category
Pharmacology and Toxicology Physiology
Identifiers
urn:nbn:se:hj:diva-28377 (URN)10.1111/1440-1681.12259 (DOI)000344348100004 ()24837032 (PubMedID)
Available from: 2015-11-25 Created: 2015-11-25 Last updated: 2020-01-29Bibliographically approved
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Identifiers
ORCID iD: ORCID iD iconorcid.org/0000-0003-3802-9661

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