Open this publication in new window or tab >>Office of Military and Veterans Health, Health and Medicine Division, National Academies of Sciences, Engineering, and Medicine, Washington, DC, United States.
Jönköping University, School of Health and Welfare, HHJ, Institute of Gerontology. Jönköping University, School of Health and Welfare, HHJ. ARN-J (Aging Research Network - Jönköping).
Department of Psychiatry, University of California San Diego, San diego, CA, United States.
Department of Public Health,Faculty of Medicine, Institute for Molecular Medicine FIMM, HiLIFE, University of Helsinki, Helsinki, Finland.
Research and Evaluation, American Institutes for Research, Washington, DC, United States.
Department of Psychology, University of Minnesota, Minneapolis, MN, United States.
Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Department of Psychology, Penn State University, University Park, PA, United States.
Danish Twin Registry, University of Southern Denmark, Odense C, Denmark.
Department of Psychiatry, University of California San Diego, San diego, CA, United States.
Department of Psychology, University of Southern California, Los Angeles, CA, United States.
Department of Psychology, University of California-Riverside, Riverside, CA, United States.
Centre for Healthy Brain Ageing (CHeBA), University of New South Wales, Sydney, NSW, Australia.
Department of Psychology, Wayne State University, Detroit, MI, United States.
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2019 (English)In: Twin Research and Human Genetics, ISSN 1832-4274, E-ISSN 1839-2628, p. 1-8Article in journal (Refereed) Epub ahead of print
Abstract [en]
The Interplay of Genes and Environment across Multiple Studies (IGEMS) is a consortium of 18 twin studies from 5 different countries (Sweden, Denmark, Finland, United States, and Australia) established to explore the nature of gene-environment (GE) interplay in functioning across the adult lifespan. Fifteen of the studies are longitudinal, with follow-up as long as 59 years after baseline. The combined data from over 76,000 participants aged 14-103 at intake (including over 10,000 monozygotic and over 17,000 dizygotic twin pairs) support two primary research emphases: (1) investigation of models of GE interplay of early life adversity, and social factors at micro and macro environmental levels and with diverse outcomes, including mortality, physical functioning and psychological functioning; and (2) improved understanding of risk and protective factors for dementia by incorporating unmeasured and measured genetic factors with a wide range of exposures measured in young adulthood, midlife and later life.
Place, publisher, year, edition, pages
Cambridge University Press, 2019
Keywords
Dementia, early life adversity, gene–environment interplay, health, socioeconomic status
National Category
Public Health, Global Health, Social Medicine and Epidemiology Medical Genetics
Identifiers
urn:nbn:se:hj:diva-46509 (URN)10.1017/thg.2019.76 (DOI)31544729 (PubMedID)2-s2.0-85072661257 (Scopus ID);HHJARNIS (Local ID);HHJARNIS (Archive number);HHJARNIS (OAI)
2019-10-092019-10-092019-10-09