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Publications (10 of 85) Show all publications
Kåreholt, I., Dahl Aslan, A. K., Siverskog, A. & Torgé, C. J. (2019). ARN-J: A beautiful kaleidoscope of gerontologists and gerontological research: Three examples of our research. In: : . Paper presented at International Association of Gerontology and Geriatrics European Region Congress 2019, 23rd – 25th May 2019, Gothenburg, Sweden.
Open this publication in new window or tab >>ARN-J: A beautiful kaleidoscope of gerontologists and gerontological research: Three examples of our research
2019 (English)Conference paper, Oral presentation with published abstract (Refereed)
National Category
Gerontology, specialising in Medical and Health Sciences
Identifiers
urn:nbn:se:hj:diva-43753 (URN)
Conference
International Association of Gerontology and Geriatrics European Region Congress 2019, 23rd – 25th May 2019, Gothenburg, Sweden
Available from: 2019-05-22 Created: 2019-05-22 Last updated: 2019-05-22Bibliographically approved
Karlsson, I. K., Ericsson, M., Wang, Y., Jylhävä, J., Hägg, S., Pedersen, N. L., . . . Dahl Aslan, A. K. (2019). DNA methylation and body mass index during late-life - a longitudinal twin study. In: : . Paper presented at International Association of Gerontology and Geriatrics European Region Congress 2019, 23rd – 25th May 2019, Gothenburg, Sweden.
Open this publication in new window or tab >>DNA methylation and body mass index during late-life - a longitudinal twin study
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2019 (English)Conference paper, Poster (with or without abstract) (Refereed)
National Category
Gerontology, specialising in Medical and Health Sciences
Identifiers
urn:nbn:se:hj:diva-43780 (URN)
Conference
International Association of Gerontology and Geriatrics European Region Congress 2019, 23rd – 25th May 2019, Gothenburg, Sweden
Available from: 2019-05-27 Created: 2019-05-27 Last updated: 2019-05-27Bibliographically approved
Jylhävä, J., Raymond, E., Reynolds, C., Finkel, D., Ericsson, M., Dahl Aslan, A. K., . . . Pedersen, N. (2019). Drivers of frailty from adulthood into old age: Results from a 27-year longitudinal population-based study in Sweden. In: : . Paper presented at International Association of Gerontology and Geriatrics European Region Congress 2019, 23rd – 25th May 2019, Gothenburg, Sweden.
Open this publication in new window or tab >>Drivers of frailty from adulthood into old age: Results from a 27-year longitudinal population-based study in Sweden
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2019 (English)Conference paper, Oral presentation with published abstract (Refereed)
National Category
Gerontology, specialising in Medical and Health Sciences
Identifiers
urn:nbn:se:hj:diva-43737 (URN)
Conference
International Association of Gerontology and Geriatrics European Region Congress 2019, 23rd – 25th May 2019, Gothenburg, Sweden
Available from: 2019-05-22 Created: 2019-05-22 Last updated: 2019-05-22Bibliographically approved
Finkel, D., Emery, C. F., Gatz, M. & Dahl Aslan, A. K. (2019). Evidence of bi-directional associations between depressive symptoms and body mass among older adults. In: : . Paper presented at The annual meeting of the Swedish Society of Epidemiology, Stockholm, Sweden.
Open this publication in new window or tab >>Evidence of bi-directional associations between depressive symptoms and body mass among older adults
2019 (English)Conference paper, Oral presentation only (Other academic)
National Category
Gerontology, specialising in Medical and Health Sciences
Identifiers
urn:nbn:se:hj:diva-43626 (URN)
Conference
The annual meeting of the Swedish Society of Epidemiology, Stockholm, Sweden
Available from: 2019-05-09 Created: 2019-05-09 Last updated: 2019-05-09
Emery, C. F., Finkel, D., Gatz, M. & Dahl Aslan, A. K. (2019). Evidence of bi-directional associations between depressive symptoms and body mass among older adults. The journals of gerontology. Series B, Psychological sciences and social sciences
Open this publication in new window or tab >>Evidence of bi-directional associations between depressive symptoms and body mass among older adults
2019 (English)In: The journals of gerontology. Series B, Psychological sciences and social sciences, ISSN 1079-5014, E-ISSN 1758-5368Article in journal (Refereed) Epub ahead of print
Abstract [en]

OBJECTIVES: Body fat, measured with body mass index (BMI), and obesity are associated with depressive symptoms. Among younger adults there is stronger evidence of obesity leading to depressive symptoms than of depressive symptoms leading to obesity, but the temporal relationship is unknown among older adults. This study utilized dual-change-score models (DCSMs) to determine the directional relationship between body mass and depressive symptoms among older adults.

METHOD: Participants (n=1743) from the Swedish Twin Registry (baseline age range 50-96 years) completed at least one assessment of BMI (nurse measurement of height and weight) and the Center for Epidemiologic Studies-Depression scale (CESD). More than half the sample completed three or more assessments, scheduled at intervals of 2-4 years. DCSMs modeled the relationship of BMI and CESD across age, both independently and as part of bivariate relationships.

RESULTS: Depressive symptoms contributed to subsequent changes in BMI after age 70, while BMI contributed to subsequent changes in depressive symptoms after age 82. Thus, there is a reciprocal relationship that may change with age. The effect was more pronounced for women.

DISCUSSION: The association of BMI and depressive symptoms is bi-directional among older adults, and it appears to be affected by both age and sex.

Place, publisher, year, edition, pages
Oxford University Press, 2019
National Category
Gerontology, specialising in Medical and Health Sciences
Identifiers
urn:nbn:se:hj:diva-43457 (URN)10.1093/geronb/gbz022 (DOI)30843043 (PubMedID);HHJARNIS (Local ID);HHJARNIS (Archive number);HHJARNIS (OAI)
Available from: 2019-04-11 Created: 2019-04-11 Last updated: 2019-04-11
Ericsson, M., Pedersen, N. L., Fors, S. & Dahl Aslan, A. K. (2019). Frailty and mortality: Investigating sex differences and socioeconomic influences using Swedish twins. In: : . Paper presented at International Association of Gerontology and Geriatrics European Region Congress 2019, 23rd – 25th May 2019, Gothenburg, Sweden.
Open this publication in new window or tab >>Frailty and mortality: Investigating sex differences and socioeconomic influences using Swedish twins
2019 (English)Conference paper, Poster (with or without abstract) (Refereed)
National Category
Gerontology, specialising in Medical and Health Sciences
Identifiers
urn:nbn:se:hj:diva-43811 (URN)
Conference
International Association of Gerontology and Geriatrics European Region Congress 2019, 23rd – 25th May 2019, Gothenburg, Sweden
Available from: 2019-05-28 Created: 2019-05-28 Last updated: 2019-05-28Bibliographically approved
Pedersen, N. & Dahl Aslan, A. K. (2019). Gene-environment interplay to explain health heterogeneity: Results from the Swedish Twin Registry. In: : . Paper presented at International Association of Gerontology and Geriatrics European Region Congress 2019, 23rd – 25th May 2019, Gothenburg, Sweden.
Open this publication in new window or tab >>Gene-environment interplay to explain health heterogeneity: Results from the Swedish Twin Registry
2019 (English)Conference paper, Oral presentation with published abstract (Refereed)
National Category
Gerontology, specialising in Medical and Health Sciences
Identifiers
urn:nbn:se:hj:diva-43758 (URN)
Conference
International Association of Gerontology and Geriatrics European Region Congress 2019, 23rd – 25th May 2019, Gothenburg, Sweden
Available from: 2019-05-22 Created: 2019-05-22 Last updated: 2019-05-22Bibliographically approved
Ericsson, M., Pedersen, N. L., Johansson, A. L. V., Fors, S. & Dahl Aslan, A. K. (2019). Life-course socioeconomic differences and social mobility in preventable and non-preventable mortality: a study of Swedish twins. International Journal of Epidemiology
Open this publication in new window or tab >>Life-course socioeconomic differences and social mobility in preventable and non-preventable mortality: a study of Swedish twins
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2019 (English)In: International Journal of Epidemiology, ISSN 0300-5771, E-ISSN 1464-3685Article in journal (Refereed) Epub ahead of print
Abstract [en]

BACKGROUND: Despite advances in life expectancy, low socioeconomic status is associated with a shorter lifespan. This study was conducted to investigate socioeconomic differences in mortality by comparing preventable with non-preventable causes of death in 39 506 participants from the Swedish Twin Registry born before 1935.

METHODS: Childhood social class, own education, own social class and social mobility were used as separate indicators of socioeconomic status. These data were linked to the Swedish Cause of Death Register. Cause of death was categorized as preventable or non-preventable mortality according to indicators presented in the Avoidable Mortality in the European Union (AMIEHS) atlas. Using Cox proportional hazard models, we tested the association between the socioeconomic measures and all-cause mortality, preventable mortality and non-preventable mortality. Additional co-twin control analyses indicated whether the associations reflected genetic confounding.

RESULTS: The social gradient for mortality was most prominent for the adult socioeconomic measures. There was a social gradient in both preventable mortality and non-preventable mortality, but with an indication of a moderately stronger effect in preventable causes of death. In analyses of social mobility, those who experienced life-time low socioeconomic status (SES) or downward social mobility had an increased mortality risk compared with those with life-time high SES and upward social mobility. Adjustments for genetic confounding did not change the observed associations for education, social class or social mobility and mortality. In the co-twin control analyses of reared-apart twins, the association between childhood social class and mortality weakened, indicating possible genetic influences on this association.

CONCLUSIONS: Our results indicate that there is an association between low adult socioeconomic status and increased mortality independent of genetic endowment. Thus, we do not find support for indirect social selection as the basis for mortality inequalities in Sweden.

Place, publisher, year, edition, pages
Oxford University Press, 2019
Keywords
Mortality, co-twin control, social gradient, social mobility, social selection, socioeconomic status
National Category
Public Health, Global Health, Social Medicine and Epidemiology
Identifiers
urn:nbn:se:hj:diva-43456 (URN)10.1093/ije/dyz042 (DOI)30929008 (PubMedID)
Available from: 2019-04-11 Created: 2019-04-11 Last updated: 2019-04-11
Hallgren, J. & Dahl Aslan, A. K. (2019). Risk of hospitalization and readmission. In: : . Paper presented at International Association of Gerontology and Geriatrics European Region Congress 2019, 23rd – 25th May 2019, Gothenburg, Sweden.
Open this publication in new window or tab >>Risk of hospitalization and readmission
2019 (English)Conference paper, Oral presentation with published abstract (Refereed)
National Category
Gerontology, specialising in Medical and Health Sciences
Identifiers
urn:nbn:se:hj:diva-43755 (URN)
Conference
International Association of Gerontology and Geriatrics European Region Congress 2019, 23rd – 25th May 2019, Gothenburg, Sweden
Available from: 2019-05-22 Created: 2019-05-22 Last updated: 2019-05-22Bibliographically approved
Silventoinen, K., Jelenkovic, A., Yokoyama, Y., Sund, R., Sugawara, M., Tanaka, M., . . . Kaprio, J. (2019). The CODATwins Project: The current status and recent findings of COllaborative Project of Development of Anthropometrical Measures in Twins. Twin Research and Human Genetics
Open this publication in new window or tab >>The CODATwins Project: The current status and recent findings of COllaborative Project of Development of Anthropometrical Measures in Twins
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2019 (English)In: Twin Research and Human Genetics, ISSN 1832-4274, E-ISSN 1839-2628Article in journal (Refereed) Epub ahead of print
Abstract [en]

The COllaborative project of Development of Anthropometrical measures in Twins (CODATwins) project is a large international collaborative effort to analyze individual-level phenotype data from twins in multiple cohorts from different environments. The main objective is to study factors that modify genetic and environmental variation of height, body mass index (BMI, kg/m2) and size at birth, and additionally to address other research questions such as long-term consequences of birth size. The project started in 2013 and is open to all twin projects in the world having height and weight measures on twins with information on zygosity. Thus far, 54 twin projects from 24 countries have provided individual-level data. The CODATwins database includes 489,981 twin individuals (228,635 complete twin pairs). Since many twin cohorts have collected longitudinal data, there is a total of 1,049,785 height and weight observations. For many cohorts, we also have information on birth weight and length, own smoking behavior and own or parental education. We found that the heritability estimates of height and BMI systematically changed from infancy to old age. Remarkably, only minor differences in the heritability estimates were found across cultural-geographic regions, measurement time and birth cohort for height and BMI. In addition to genetic epidemiological studies, we looked at associations of height and BMI with education, birth weight and smoking status. Within-family analyses examined differences within same-sex and opposite-sex dizygotic twins in birth size and later development. The CODATwins project demonstrates the feasibility and value of international collaboration to address gene-by-exposure interactions that require large sample sizes and address the effects of different exposures across time, geographical regions and socioeconomic status. 

Place, publisher, year, edition, pages
Cambridge University Press, 2019
Keywords
birth size, BMI, education, height, heritability, international comparisons, Twins, adult, article, birth weight, body mass, controlled study, disease course, dizygotic twins, feasibility study, female, genetic susceptibility, genetic variation, human, infancy, major clinical study, male, sample size, smoking, social status
National Category
Public Health, Global Health, Social Medicine and Epidemiology
Identifiers
urn:nbn:se:hj:diva-45600 (URN)10.1017/thg.2019.35 (DOI)31364586 (PubMedID)2-s2.0-85070056867 (Scopus ID);HHJARNIS (Local ID);HHJARNIS (Archive number);HHJARNIS (OAI)
Available from: 2019-08-19 Created: 2019-08-19 Last updated: 2019-08-19
Organisations
Identifiers
ORCID iD: ORCID iD iconorcid.org/0000-0002-6305-8993

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