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Wikby, Anders
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Strindhall, J., Löfgren, S., Främsth, C., Matussek, A., Bengner, M., Ernerudh, J. & Wikby, A. (2017). CD4/CD8 ratio < 1 is associated with lymphocyte subsets, CMV and gender in 71-year old individuals: 5-Year follow-up of the Swedish HEXA Immune Longitudinal Study. Experimental Gerontology, 95, 82-87
Åpne denne publikasjonen i ny fane eller vindu >>CD4/CD8 ratio < 1 is associated with lymphocyte subsets, CMV and gender in 71-year old individuals: 5-Year follow-up of the Swedish HEXA Immune Longitudinal Study
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2017 (engelsk)Inngår i: Experimental Gerontology, ISSN 0531-5565, E-ISSN 1873-6815, Vol. 95, s. 82-87Artikkel i tidsskrift (Fagfellevurdert) Published
sted, utgiver, år, opplag, sider
Elsevier, 2017
HSV kategori
Identifikatorer
urn:nbn:se:hj:diva-36041 (URN)10.1016/j.exger.2017.03.020 (DOI)000404493500012 ()28476585 (PubMedID)2-s2.0-85019771545 (Scopus ID)
Tilgjengelig fra: 2017-06-13 Laget: 2017-06-13 Sist oppdatert: 2018-01-13bibliografisk kontrollert
Pawelec, G., Derhovanessian, E., Larbi, A., Strindhall, J. & Wikby, A. (2009). Cytomegalovirus and human immunosenescence. Reviews in Medical Virology, 19(1), 47-56
Åpne denne publikasjonen i ny fane eller vindu >>Cytomegalovirus and human immunosenescence
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2009 (engelsk)Inngår i: Reviews in Medical Virology, ISSN 1052-9276, E-ISSN 1099-1654, Vol. 19, nr 1, s. 47-56Artikkel, forskningsoversikt (Fagfellevurdert) Published
Abstract [en]

'Immunosenescence' is all imprecise term used to describe deleterious age-associated changes to immune parameters observed in all mammals studied so far. Primarily anecdotal evidence implies that failing immunity is responsible for the increased incidence and severity of infectious disease in old people. However, there is a serious dearth of accurate hard data concerning the actual cause of death in the elderly and the contribution thereto of the multitude of age-associated alterations measured in the immune system. Cross-sectional studies comparing those currently young With those currently old reveal a large number of differences in the distribution of immune cell types in the blood, and to some extent the functional integrity of those cells. Many of these parameters differ markedly between individuals infected with CMV and uninfected people, regardless of infection with other persistent herpesviruses. The adaptive arm of immunity appears to be more seriously affected than the innate arm, particularly the T lymphocytes. However, cross-sectional studies suffer the disadvantage that like is not being compared with like, because the conditions applied during the entire life course of the currently elderly were different from those applied now to the young. These differences in environment, nutrition, pathology and possibly genetics, rather than merely age, may be expected to influence the parameters studied. Moreover, pathogen exposure of the currently elderly was also different from contemporary exposure, probably including CMV. Some of the problems associated with cross-sectional studies can be overcome by performing longitudinal studies, as pointed out in an earlier analysis of the Baltimore Longitudinal Ageing study looking at lymphocyte numbers. However, longitudinal studies are challenging in humans. L Nonetheless, the pioneering Swedish OCTO/NONA studies of the very elderly which for the first time included a range of immune parameters, have identified a set of immune parameters predicting mortality at 2, 4 and 6 year follow-up; CMV infection makes a material contribution to this so-called immune risk profile (IRP)'. Whether the IRP is informative in younger individuals and the mechanism of the CMV effect is discussed in this review. 

sted, utgiver, år, opplag, sider
John Wiley & Sons, 2009
HSV kategori
Identifikatorer
urn:nbn:se:hj:diva-9294 (URN)10.1002/rmv.598 (DOI)000262519600004 ()19035529 (PubMedID)2-s2.0-60549096353 (Scopus ID)
Tilgjengelig fra: 2009-06-04 Laget: 2009-06-04 Sist oppdatert: 2019-08-30bibliografisk kontrollert
Wikby, A., Månsson, I. A., Johansson, B., Strindhall, J. & Nilsson, S. E. (2008). The immune risk profile is associated with age and gender: findings from three Swedish population studies of individuals 20-100 years of age.. Biogerontology (Dordrecht), 9(5), 299-308
Åpne denne publikasjonen i ny fane eller vindu >>The immune risk profile is associated with age and gender: findings from three Swedish population studies of individuals 20-100 years of age.
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2008 (engelsk)Inngår i: Biogerontology (Dordrecht), ISSN 1389-5729, E-ISSN 1573-6768, Vol. 9, nr 5, s. 299-308Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Earlier we identified an Immune Risk Profile (IRP) of very old individuals, 86-94 years of age, characterised by an inverted CD4/CD8 ratio and associated with persistent cytomegalovirus infection and an increase in the numbers of CD3+CD8+CD28- cells. In the present study we included data from a population-based sample in the age range of 20-79 years to examine the prevalence of individuals with an inverted CD4/CD8 ratio relative to age and gender across the entire adult lifespan. Immunological monitoring that was conducted included analysis of the numbers of T-cells in the subsets CD3+, CD3+CD4+, and CD3+CD8+ as well as CD3+CD8+CD28+, CD3+CD8+CD28-, and CD8+CD45RA+CCR7+. There was found to be a significant lowering of the numbers of CD3+, CD3+CD4+, and CD3+CD8+, and of the CD8+CD45RA+CCR7+ cells across the adult life-span. Notably, the prevalence of individuals with an inverted CD4/CD8 ratio increased from about 8% in the age range of 20-59 years to about 16% in the age range of 60-94 years. The mortality rate in individuals with an inverted CD4/CD8 ratio also increased significantly above the age of 60. Interestingly, the proportion of individuals with an inverted CD4/CD8 ratio was found to be significantly higher in men, whereas the numbers of CD3+CD4+ helper and CD8+CD45RA+CCR7+ naive cells and the CD4/CD8 ratio were found to be significantly higher in women. These results highlight the importance of functioning of the thymus in the development of IRP and may partly account for the differences between sexes in terms of longevity.

sted, utgiver, år, opplag, sider
Springer, 2008
Emneord
immune risk; T-cells; age; gender
HSV kategori
Identifikatorer
urn:nbn:se:hj:diva-7041 (URN)10.1007/s10522-008-9138-6 (DOI)000258653600002 ()18369735 (PubMedID)2-s2.0-50649111879 (Scopus ID)
Tilgjengelig fra: 2008-12-10 Laget: 2008-12-10 Sist oppdatert: 2019-09-02bibliografisk kontrollert
Koch, S., Larbi, A., Ozcelik, D., Solana, R., Gouttefangeas, C., Attig, S., . . . Pawelec, G. (2007). Cytomegalovirus infection: a driving force in human T cell immunosenescence.. Annals of the New York Academy of Sciences (1114), 23-35
Åpne denne publikasjonen i ny fane eller vindu >>Cytomegalovirus infection: a driving force in human T cell immunosenescence.
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2007 (engelsk)Inngår i: Annals of the New York Academy of Sciences, ISSN 0077-8923, E-ISSN 1749-6632, nr 1114, s. 23-35Artikkel i tidsskrift (Fagfellevurdert) Published
Identifikatorer
urn:nbn:se:hj:diva-4387 (URN)17986574 (PubMedID)
Tilgjengelig fra: 2007-11-09 Laget: 2007-11-09 Sist oppdatert: 2017-12-12bibliografisk kontrollert
Cherfan, P., Tompa, A., Wikby, A., Löfgren, S. & Jonasson, L. (2007). Effects of simvastatin on human T cells in vivo. Atherosclerosis, 193(1), 186-192
Åpne denne publikasjonen i ny fane eller vindu >>Effects of simvastatin on human T cells in vivo
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2007 (engelsk)Inngår i: Atherosclerosis, ISSN 0021-9150, E-ISSN 1879-1484, Vol. 193, nr 1, s. 186-192Artikkel i tidsskrift (Fagfellevurdert) Published
Emneord
Adult, Apolipoproteins/blood, C-Reactive Protein/metabolism, Concanavalin A/pharmacology, Double-Blind Method, Enterotoxins/pharmacology, HLA-DR Antigens/blood, Humans, Hydroxymethylglutaryl-CoA Reductase Inhibitors/*pharmacology, Hypercholesterolemia/blood/drug therapy/immunology, Interleukin-2 Receptor alpha Subunit/blood, L-Selectin/blood, Lipids/blood, Male, Middle Aged, Simvastatin/*pharmacology, T-Lymphocyte Subsets/drug effects, T-Lymphocytes/*drug effects/immunology/metabolism
Identifikatorer
urn:nbn:se:hj:diva-4293 (URN)16860807 (PubMedID)
Tilgjengelig fra: 2007-10-31 Laget: 2007-10-31 Sist oppdatert: 2017-12-12bibliografisk kontrollert
Fülöp, T., Larbi, A., Hirokawa, K., Mocchegiani, E., Lesourds, B., Castle, S., . . . Pawelec, G. (2007). Immunosupportive therapies in aging. Clinical Interventions in Aging, 2(1), 33-54
Åpne denne publikasjonen i ny fane eller vindu >>Immunosupportive therapies in aging
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2007 (engelsk)Inngår i: Clinical Interventions in Aging, ISSN 1176-9092, Vol. 2, nr 1, s. 33-54Artikkel i tidsskrift (Fagfellevurdert) Published
HSV kategori
Identifikatorer
urn:nbn:se:hj:diva-4742 (URN)18044074 (PubMedID)
Tilgjengelig fra: 2007-12-03 Laget: 2007-12-03bibliografisk kontrollert
Nilsson, B.-O., Skogh, T., Ernerudh, J., Johansson, B., Löfgren, S., Wikby, A. & Dahle, C. (2006). Antinuclear antibodies in the oldest-old women and men. Journal of Autoimmunity, 27(4), 281-288
Åpne denne publikasjonen i ny fane eller vindu >>Antinuclear antibodies in the oldest-old women and men
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2006 (engelsk)Inngår i: Journal of Autoimmunity, ISSN 0896-8411, E-ISSN 1095-9157, Vol. 27, nr 4, s. 281-288Artikkel i tidsskrift (Fagfellevurdert) Published
Emneord
Adolescent, Adult, Aged, Aged; 80 and over, Aging/*immunology, Antibodies; Antinuclear/genetics/*immunology, CD4-Positive T-Lymphocytes/immunology, CD8-Positive T-Lymphocytes/immunology, Cytomegalovirus/immunology, Cytomegalovirus Infections/immunology, Female, Humans, Male, Middle Aged
Identifikatorer
urn:nbn:se:hj:diva-4288 (URN)17156973 (PubMedID)
Tilgjengelig fra: 2007-11-15 Laget: 2007-11-15 Sist oppdatert: 2017-12-12bibliografisk kontrollert
Pawelec, G., Koch, S., Franceschi, C. & Wikby, A. (2006). Human immunosenescence: does it have an infectious component?. Annals of the New York Academy of Sciences, 1067, 56-65
Åpne denne publikasjonen i ny fane eller vindu >>Human immunosenescence: does it have an infectious component?
2006 (engelsk)Inngår i: Annals of the New York Academy of Sciences, ISSN 0077-8923, E-ISSN 1749-6632, Vol. 1067, s. 56-65Artikkel i tidsskrift (Fagfellevurdert) Published
Emneord
Aged, Aging/*immunology, Animals, CD8-Positive T-Lymphocytes/*immunology, Cytomegalovirus/*immunology/pathogenicity, Cytomegalovirus Infections/*immunology/virology, Humans, Immunity/*immunology, Longitudinal Studies, Models; Immunological
Identifikatorer
urn:nbn:se:hj:diva-4294 (URN)16803971 (PubMedID)
Tilgjengelig fra: 2007-10-31 Laget: 2007-10-31 Sist oppdatert: 2017-12-12bibliografisk kontrollert
DelaRosa, O., Pawelec, G., Peralbo, E., Wikby, A., Mariani, E., Mocchegiani, E., . . . Solana, R. (2006). Immunological biomarkers of ageing in man: changes in both innate and adaptive immunity are associated with health and longevity.. Biogerontology (Dordrecht), 7(5-6), 471-481
Åpne denne publikasjonen i ny fane eller vindu >>Immunological biomarkers of ageing in man: changes in both innate and adaptive immunity are associated with health and longevity.
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2006 (engelsk)Inngår i: Biogerontology (Dordrecht), ISSN 1389-5729, E-ISSN 1573-6768, Vol. 7, nr 5-6, s. 471-481Artikkel i tidsskrift (Fagfellevurdert) Published
Emneord
Aged; 80 and over, Aging/*immunology/metabolism, Antigen Presentation, Biological Markers/metabolism, Cytomegalovirus Infections/immunology/metabolism, Humans, Immunity; Cellular, Immunity; Natural, Killer Cells; Natural/*immunology/metabolism, Longevity/*immunology, Zinc/*metabolism
HSV kategori
Identifikatorer
urn:nbn:se:hj:diva-4292 (URN)16957868 (PubMedID)
Tilgjengelig fra: 2007-10-31 Laget: 2007-10-31 Sist oppdatert: 2017-12-12bibliografisk kontrollert
Pawelec, G., Koch, S., Gouttefangeas, C. & Wikby, A. (2006). Immunorejuvenation in the elderly. Rejuvenation Research, 9(1), 111-116
Åpne denne publikasjonen i ny fane eller vindu >>Immunorejuvenation in the elderly
2006 (engelsk)Inngår i: Rejuvenation Research, ISSN 1549-1684, Vol. 9, nr 1, s. 111-116Artikkel i tidsskrift (Fagfellevurdert) Published
Emneord
Aged, Aging/*immunology, CD8-Positive T-Lymphocytes/immunology, Cytomegalovirus/immunology, Cytomegalovirus Infections/immunology, Humans, Immunity; Cellular, Infant
HSV kategori
Identifikatorer
urn:nbn:se:hj:diva-4296 (URN)16608407 (PubMedID)
Tilgjengelig fra: 2007-10-31 Laget: 2007-10-31bibliografisk kontrollert
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